The Enzyme Database

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EC 2.3.1.302     
Accepted name: hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase
Reaction: (1) (E)-4-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA
(2) (E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA
Glossary: avenanthramide A = 5-hydroxy-2-[(2E)-3-(4-hydroxyphenyl)prop-2-enamido]benzoate
avenanthramide C = 2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enamido]-5-hydroxybenzoate
Other name(s): HHT1 (gene name); HHT4 (gene name)
Systematic name: hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase
Comments: The enzyme participates in the biosynthesis of avenanthramides, phenolic alkaloids found mainly in oats (Avena sativa). It is related to EC 2.3.1.133, shikimate O-hydroxycinnamoyltransferase. The enzyme from oat does not accept feruloyl-CoA as a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ishihara, A., Matsukawa, T., Miyagawa, H., Ueno, T. and Mayama, S. Induction of hydroxycinnamoyl-CoA: hydroxyanthranilate N-hydroxycinnamoyltransferase (HHT) activity in oat leaves by victorin C. Z. Naturforsch. C 52 (1997) 756–760. [DOI]
2.  Yang, Q., Trinh, H.X., Imai, S., Ishihara, A., Zhang, L., Nakayashiki, H., Tosa, Y. and Mayama, S. Analysis of the involvement of hydroxyanthranilate hydroxycinnamoyltransferase and caffeoyl-CoA 3-O-methyltransferase in phytoalexin biosynthesis in oat. Mol. Plant Microbe Interact. 17 (2004) 81–89. [DOI] [PMID: 14714871]
3.  D'Auria, J.C. Acyltransferases in plants: a good time to be BAHD. Curr. Opin. Plant Biol. 9 (2006) 331–340. [DOI] [PMID: 16616872]
4.  Bontpart, T., Cheynier, V., Ageorges, A. and Terrier, N. BAHD or SCPL acyltransferase? What a dilemma for acylation in the world of plant phenolic compounds. New Phytol. 208 (2015) 695–707. [DOI] [PMID: 26053460]
5.  Li, Z., Chen, Y., Meesapyodsuk, D. and Qiu, X. The biosynthetic pathway of major avenanthramides in oat. Metabolites 9 (2019) . [DOI] [PMID: 31394723]
[EC 2.3.1.302 created 2021]
 
 


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