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Your query returned 6 entries. Printable version
EC | 1.1.1.362 | ||||||
Accepted name: | aklaviketone reductase | ||||||
Reaction: | aklavinone + NADP+ = aklaviketone + NADPH + H+ | ||||||
For diagram of aflatoxin biosynthesis, click here | |||||||
Glossary: | aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate |
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Other name(s): | dauE (gene name); aknU (gene name) | ||||||
Systematic name: | aklavinone:NADP+ oxidoreductase | ||||||
Comments: | The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 1.14.13.180 | ||||||
Accepted name: | aklavinone 12-hydroxylase | ||||||
Reaction: | aklavinone + NADPH + H+ + O2 = ε-rhodomycinone + NADP+ + H2O | ||||||
For diagram of aflatoxin biosynthesis, click here | |||||||
Glossary: | aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate ε-rhodomycinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7,12-pentahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate |
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Other name(s): | DnrF; RdmE; aklavinone 11-hydroxylase (incorrect) | ||||||
Systematic name: | aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating) | ||||||
Comments: | The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 2.4.1.326 | ||||||
Accepted name: | aklavinone 7-L-rhodosaminyltransferase | ||||||
Reaction: | dTDP-β-L-rhodosamine + aklavinone = dTDP + aclacinomycin T | ||||||
For diagram of aklavinone biosynthesis, click here | |||||||
Glossary: | dTDP-β-L-rhodosamine = dTDP-2,3,6-trideoxy-3-dimethylamino-β-L-lyxo-hexose aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone |
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Other name(s): | AknS/AknT; aklavinone 7-β-L-rhodosaminyltransferase; dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase | ||||||
Systematic name: | dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase (configuration-inverting) | ||||||
Comments: | Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-β-L-fucose. Involved in the biosynthesis of other aclacinomycins. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 2.4.1.327 | ||||||
Accepted name: | aclacinomycin-T 2-deoxy-L-fucose transferase | ||||||
Reaction: | dTDP-2-deoxy-β-L-fucose + aclacinomycin T = dTDP + aclacinomycin S | ||||||
For diagram of aclacinomycin A and Y biosynthesis, click here | |||||||
Glossary: | idarubicin = (7S,9S)-9-acetyl-7-(3-amino-2,3,6-trideoxy-β-L-lyxo-hexosyloxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione aclacinomycin S = 7-O-(2-deoxy-α-L-fucosyl-(1→4)-rhodosaminyl)aklavinone aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone |
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Other name(s): | AknK | ||||||
Systematic name: | dTDP-2-deoxy-β-L-fucose:7-(α-L-rhodosaminyl)aklavinone 2-deoxy-α-L-fucosyltransferase | ||||||
Comments: | The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 3.1.1.95 | ||||||
Accepted name: | aclacinomycin methylesterase | ||||||
Reaction: | aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol | ||||||
For diagram of aflatoxin biosynthesis, click here | |||||||
Glossary: | aclacinomycin T = 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1-naphthacenecarboxylic acid methyl ester = methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate 15-demethoxyaclacinomycin T = (1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1-naphthacenecarboxylic acid = (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylic acid |
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Other name(s): | RdmC; aclacinomycin methyl esterase | ||||||
Systematic name: | aclacinomycin T acylhydrolase | ||||||
Comments: | The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 5.5.1.23 | ||||||
Accepted name: | aklanonic acid methyl ester cyclase | ||||||
Reaction: | aklaviketone = methyl aklanonate | ||||||
For diagram of aklavinone biosynthesis, click here | |||||||
Glossary: | aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate methyl aklanonate = methyl [4,5-dihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetate |
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Other name(s): | dauD (gene name); aknH (gene name); dnrD (gene name); methyl aklanonate cyclase; methyl aklanonate-aklaviketone isomerase (cyclizing); aklaviketone lyase (decyclizing) | ||||||
Systematic name: | aklaviketone lyase (ring-opening) | ||||||
Comments: | The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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