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Your query returned 3 entries. Printable version
EC | 2.4.1.326 | ||||
Accepted name: | aklavinone 7-L-rhodosaminyltransferase | ||||
Reaction: | dTDP-β-L-rhodosamine + aklavinone = dTDP + aclacinomycin T | ||||
For diagram of aklavinone biosynthesis, click here | |||||
Glossary: | dTDP-β-L-rhodosamine = dTDP-2,3,6-trideoxy-3-dimethylamino-β-L-lyxo-hexose aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone |
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Other name(s): | AknS/AknT; aklavinone 7-β-L-rhodosaminyltransferase; dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase | ||||
Systematic name: | dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase (configuration-inverting) | ||||
Comments: | Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-β-L-fucose. Involved in the biosynthesis of other aclacinomycins. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.4.1.327 | ||||
Accepted name: | aclacinomycin-T 2-deoxy-L-fucose transferase | ||||
Reaction: | dTDP-2-deoxy-β-L-fucose + aclacinomycin T = dTDP + aclacinomycin S | ||||
For diagram of aclacinomycin A and Y biosynthesis, click here | |||||
Glossary: | idarubicin = (7S,9S)-9-acetyl-7-(3-amino-2,3,6-trideoxy-β-L-lyxo-hexosyloxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione aclacinomycin S = 7-O-(2-deoxy-α-L-fucosyl-(1→4)-rhodosaminyl)aklavinone aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone |
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Other name(s): | AknK | ||||
Systematic name: | dTDP-2-deoxy-β-L-fucose:7-(α-L-rhodosaminyl)aklavinone 2-deoxy-α-L-fucosyltransferase | ||||
Comments: | The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 3.1.1.95 | ||||
Accepted name: | aclacinomycin methylesterase | ||||
Reaction: | aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol | ||||
For diagram of aflatoxin biosynthesis, click here | |||||
Glossary: | aclacinomycin T = 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1-naphthacenecarboxylic acid methyl ester = methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate 15-demethoxyaclacinomycin T = (1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1-naphthacenecarboxylic acid = (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylic acid |
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Other name(s): | RdmC; aclacinomycin methyl esterase | ||||
Systematic name: | aclacinomycin T acylhydrolase | ||||
Comments: | The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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