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Your query returned 4 entries. Printable version
EC | 1.1.3.45 | ||||||
Accepted name: | aclacinomycin-N oxidase | ||||||
Reaction: | aclacinomycin N + O2 = aclacinomycin A + H2O2 | ||||||
For diagram of aclacinomycin A and Y biosynthesis, click here | |||||||
Glossary: | aclacinomycin N = 2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2S,5S,6S)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-1,2,3,4,6,11-hexahydronaphthacene-1-carboxylic acid methyl ester aclacinomycin A = 2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-1,2,3,4,6,11-hexahydronaphthacene-1-carboxylic acid methyl ester |
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Other name(s): | AknOx (ambiguous); aclacinomycin oxidoreductase (ambiguous) | ||||||
Systematic name: | aclacinomycin-N:oxygen oxidoreductase | ||||||
Comments: | A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y (cf. EC 1.3.3.14, aclacinomycin A oxidase). | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 1.3.3.14 | ||||||
Accepted name: | aclacinomycin-A oxidase | ||||||
Reaction: | aclacinomycin A + O2 = aclacinomycin Y + H2O2 | ||||||
For diagram of aclacinomycin A and Y biosynthesis, click here | |||||||
Glossary: | aclacinomycin A = 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]naphthacene-1-carboxylic acid methyl ester aclacinomycin Y = 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]naphthacene-1-carboxylic acid methyl ester |
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Other name(s): | AknOx (ambiguous); aclacinomycin oxidoreductase (ambiguous) | ||||||
Systematic name: | aclacinomycin-A:oxygen oxidoreductase | ||||||
Comments: | A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A (cf. EC 1.1.3.45) and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 2.4.1.326 | ||||||
Accepted name: | aklavinone 7-L-rhodosaminyltransferase | ||||||
Reaction: | dTDP-β-L-rhodosamine + aklavinone = dTDP + aclacinomycin T | ||||||
For diagram of aklavinone biosynthesis, click here | |||||||
Glossary: | dTDP-β-L-rhodosamine = dTDP-2,3,6-trideoxy-3-dimethylamino-β-L-lyxo-hexose aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone |
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Other name(s): | AknS/AknT; aklavinone 7-β-L-rhodosaminyltransferase; dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase | ||||||
Systematic name: | dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase (configuration-inverting) | ||||||
Comments: | Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-β-L-fucose. Involved in the biosynthesis of other aclacinomycins. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 2.4.1.327 | ||||||
Accepted name: | aclacinomycin-T 2-deoxy-L-fucose transferase | ||||||
Reaction: | dTDP-2-deoxy-β-L-fucose + aclacinomycin T = dTDP + aclacinomycin S | ||||||
For diagram of aclacinomycin A and Y biosynthesis, click here | |||||||
Glossary: | idarubicin = (7S,9S)-9-acetyl-7-(3-amino-2,3,6-trideoxy-β-L-lyxo-hexosyloxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione aclacinomycin S = 7-O-(2-deoxy-α-L-fucosyl-(1→4)-rhodosaminyl)aklavinone aclacinomycin T = 7-O-(α-L-rhodosaminyl)aklavinone |
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Other name(s): | AknK | ||||||
Systematic name: | dTDP-2-deoxy-β-L-fucose:7-(α-L-rhodosaminyl)aklavinone 2-deoxy-α-L-fucosyltransferase | ||||||
Comments: | The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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