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Your query returned 3 entries. Printable version
EC | 1.14.13.98 | ||||||||||
Transferred entry: | cholesterol 24-hydroxylase. Now EC 1.14.14.25, cholesterol 24-hydroxylase | ||||||||||
EC | 1.14.14.25 | ||||||||||
Accepted name: | cholesterol 24-hydroxylase | ||||||||||
Reaction: | cholesterol + [reduced NADPH—hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3β,24-diol + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||||
For diagram of cholic acid biosynthesis (sidechain), click here | |||||||||||
Glossary: | cholesterol = cholest-5-en-3β-ol (24S)-24-hydroxycholesterol = (24S)-cholest-5-ene-3β,24-diol |
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Other name(s): | cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1 | ||||||||||
Systematic name: | cholesterol,NADPH—hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating) | ||||||||||
Comments: | A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood—brain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase [3]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 50812-30-1, 213327-78-7 | ||||||||||
References: |
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EC | 2.3.2.33 | ||||||||||
Accepted name: | RCR-type E3 ubiquitin transferase | ||||||||||
Reaction: | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine (overall reaction) (1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RCR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine (1b) [RCR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [RCR-type E3 ubiquitin transferase]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine |
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Glossary: | RCR = RING-Cys-Relay RING = Really Interesting New Gene |
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Other name(s): | MYCBP2; PHR1 | ||||||||||
Systematic name: | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming; RCR-type) | ||||||||||
Comments: | RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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