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Your query returned 3 entries. Printable version
EC | 2.3.1.234 | ||||||||
Accepted name: | N6-L-threonylcarbamoyladenine synthase | ||||||||
Reaction: | L-threonylcarbamoyladenylate + adenine37 in tRNA = AMP + N6-L-threonylcarbamoyladenine37 in tRNA | ||||||||
For diagram of N6-L-threonylcarbamoyladenosine37 modified tRNA biosynthesis, click here | |||||||||
Glossary: | N6-L-threonylcarbamoyladenine37 = t6A37 | ||||||||
Other name(s): | t6A synthase; Kae1; ygjD (gene name); Qri7 | ||||||||
Systematic name: | L-threonylcarbamoyladenylate:adenine37 in tRNA N6-L-threonylcarbamoyltransferase | ||||||||
Comments: | The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
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EC | 2.6.99.4 | ||||||||
Transferred entry: | N6-L-threonylcarbamoyladenine synthase. Now EC 2.3.1.234, N6-L-threonylcarbamoyladenine synthase. | ||||||||
EC | 2.8.4.5 | ||||||||
Accepted name: | tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase | ||||||||
Reaction: | N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = 2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5′-deoxyadenosine + electron acceptor (overall reaction) (1a) N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced electron acceptor = 2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA + (sulfur carrier) + L-methionine + 5′-deoxyadenosine + electron acceptor (1b) S-adenosyl-L-methionine + 2-sulfanyl-N6-L-threonylcarbamoyladenine37 in tRNA = S-adenosyl-L-homocysteine + 2-(methylsulfanyl)-N6-L-threonylcarbamoyladenine37 in tRNA |
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For diagram of N6-L-Threonylcarbamoyladenosine37 modified tRNA biosynthesis, click here | |||||||||
Glossary: | N6-L-threonylcarbamoyladenine37 = t6A37 2-sulfanyl-N6-L-threonylcarbamoyladenine37 = ms2t6A37 |
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Other name(s): | MtaB; methylthio-threonylcarbamoyl-adenosine transferase B; CDKAL1 (gene name); tRNA (N6-L-threonylcarbamoyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-methylthiotransferase | ||||||||
Systematic name: | tRNA (N6-L-threonylcarbamoyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-(methylsulfanyl)transferase | ||||||||
Comments: | The enzyme, which is a member of the S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes superfamily, binds two [4Fe-4S] clusters as well as the transferred sulfur. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
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