EC |
2.7.1.192 |
Accepted name: |
protein-Nπ-phosphohistidine—N-acetylmuramate phosphotransferase |
Reaction: |
[protein]-Nπ-phospho-L-histidine + N-acetyl-D-muramate[side 1] = [protein]-L-histidine + N-acetyl-D-muramate 6-phosphate[side 2] |
Other name(s): |
murP (gene name); N-acetylmuramic acid PTS permease; EIINAcMur; Enzyme IINAcMur |
Systematic name: |
protein-Nπ-phospho-L-histidine:N-acetyl-D-muramate Nπ-phosphotransferase |
Comments: |
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate—protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Dahl, U., Jaeger, T., Nguyen, B.T., Sattler, J.M. and Mayer, C. Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid. J. Bacteriol. 186 (2004) 2385–2392. [DOI] [PMID: 15060041] |
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[EC 2.7.1.192 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.192] |
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EC |
2.7.1.221 |
Accepted name: |
N-acetylmuramate 1-kinase |
Reaction: |
ATP + N-acetyl-D-muramate = ADP + N-acetyl-α-D-muramate 1-phosphate |
Glossary: |
N-acetyl-D-muramate = 3-O-[(1R)-1-carboxyethyl]-2-acetoxy-2-deoxy-D-glucopyranose |
Other name(s): |
amgK (gene name) |
Systematic name: |
ATP:N-acetyl-D-muramate 1-phosphotransferase |
Comments: |
The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Gisin, J., Schneider, A., Nagele, B., Borisova, M. and Mayer, C. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nat. Chem. Biol. 9 (2013) 491–493. [DOI] [PMID: 23831760] |
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[EC 2.7.1.221 created 2017] |
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EC |
3.1.3.105 |
Accepted name: |
N-acetyl-D-muramate 6-phosphate phosphatase |
Reaction: |
N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-muramate + phosphate |
Other name(s): |
mupP (gene name) |
Systematic name: |
N-acetyl-D-muramate 6-phosphate phosphohydrolase |
Comments: |
The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Borisova, M., Gisin, J. and Mayer, C. The N-acetylmuramic acid 6-phosphate phosphatase MupP completes the Pseudomonas peptidoglycan recycling pathway leading to intrinsic fosfomycin resistance. mBio 8 (2017) e00092-17. [DOI] [PMID: 28351914] |
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[EC 3.1.3.105 created 2017] |
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