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Your query returned 1 entry. Printable version
EC | 4.4.1.35 | ||||
Accepted name: | L-cystine β-lyase | ||||
Reaction: | L-cystine + H2O = L-thiocysteine + pyruvate + NH3 (overall reaction) (1a) L-cystine = L-thiocysteine + 2-aminoprop-2-enoate (1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous) (1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous) |
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Glossary: | L-thiocysteine = S-sulfanyl-L-cysteine | ||||
Other name(s): | CORI3 (gene name) | ||||
Systematic name: | L-cystine thiocysteine-lyase (deaminating; pyruvate-forming) | ||||
Comments: | A pyridoxal 5′-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-thiocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from Brassica oleracea var. italica (broccoli) does not act on cysteine or cystathionine. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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