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Your query returned 7 entries. Printable version
EC | 1.1.1.135 | ||||||||||||
Accepted name: | GDP-6-deoxy-D-talose 4-dehydrogenase | ||||||||||||
Reaction: | GDP-6-deoxy-α-D-talose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ | ||||||||||||
For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose GDP-6-deoxy-α-D-talose = GDP-α-D-pneumose |
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Other name(s): | guanosine diphospho-6-deoxy-D-talose dehydrogenase; GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Systematic name: | GDP-6-deoxy-α-D-talose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37250-66-1 | ||||||||||||
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EC | 1.1.1.187 | ||||||||||||
Accepted name: | GDP-4-dehydro-D-rhamnose reductase | ||||||||||||
Reaction: | (1) GDP-α-D-rhamnose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ (2) GDP-6-deoxy-α-D-talose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ |
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For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-α-D-rhamnose = GDP-6-deoxy-α-D-mannose GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose GDP-6-deoxy-α-D-talose = GDP-α-D-pneumose |
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Other name(s): | GDP-4-keto-6-deoxy-D-mannose reductase; GDP-4-keto-D-rhamnose reductase; guanosine diphosphate-4-keto-D-rhamnose reductase; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase; GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Systematic name: | GDP-4-dehydro-α-D-rhamnose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Comments: | The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9075-56-3 | ||||||||||||
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EC | 1.1.1.271 | ||||||||||||
Accepted name: | GDP-L-fucose synthase | ||||||||||||
Reaction: | GDP-β-L-fucose + NADP+ = GDP-4-dehydro-α-D-rhamnose + NADPH + H+ | ||||||||||||
For diagram of GDP-L-Fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose | ||||||||||||
Other name(s): | GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) | ||||||||||||
Systematic name: | GDP-β-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) | ||||||||||||
Comments: | Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 113756-18-6 | ||||||||||||
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EC | 1.1.1.281 | ||||||||||||
Accepted name: | GDP-4-dehydro-6-deoxy-D-mannose reductase | ||||||||||||
Reaction: | GDP-α-D-rhamnose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ | ||||||||||||
For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-α-D-rhamnose = GDP-6-deoxy-α-D-mannose GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose |
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Other name(s): | GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous]; GDP-6-deoxy-D-lyxo-4-hexulose reductase; Rmd; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming); GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) | ||||||||||||
Systematic name: | GDP-α-D-rhamnose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Comments: | This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-α-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 2.6.1.102 | ||||||||||||
Accepted name: | GDP-perosamine synthase | ||||||||||||
Reaction: | GDP-α-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-α-D-rhamnose + L-glutamate | ||||||||||||
Glossary: | GDP-α-D-perosamine = GDP-4-amino-4,6-dideoxy-α-D-mannose GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose |
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Other name(s): | RfbE; GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase; GDP-perosamine synthetase; PerA; GDP-4-amino-4,6-dideoxy-α-D-mannose:2-oxoglutarate aminotransferase | ||||||||||||
Systematic name: | GDP-α-D-perosamine:2-oxoglutarate aminotransferase | ||||||||||||
Comments: | A pyridoxal 5′-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-α-D-perosamine synthesis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 4.2.1.47 | ||||||||||||
Accepted name: | GDP-mannose 4,6-dehydratase | ||||||||||||
Reaction: | GDP-α-D-mannose = GDP-4-dehydro-α-D-rhamnose + H2O | ||||||||||||
For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose | ||||||||||||
Other name(s): | guanosine 5′-diphosphate-D-mannose oxidoreductase; guanosine diphosphomannose oxidoreductase; guanosine diphosphomannose 4,6-dehydratase; GDP-D-mannose dehydratase; GDP-D-mannose 4,6-dehydratase; Gmd; GDP-mannose 4,6-hydro-lyase; GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming) | ||||||||||||
Systematic name: | GDP-α-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-α-D-rhamnose-forming) | ||||||||||||
Comments: | The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-α-D-rhamnose and GDP-β-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37211-59-9 | ||||||||||||
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EC | 4.2.1.168 | ||||||||||||
Accepted name: | GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase | ||||||||||||
Reaction: | GDP-4-dehydro-α-D-rhamnose + L-glutamate = GDP-4-dehydro-3,6-dideoxy-α-D-mannose + 2-oxoglutarate + NH3 (overall reaction) (1a) GDP-4-dehydro-α-D-rhamnose + L-glutamate = 2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] + 2-oxoglutarate + H2O (1b) 2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] = 2-GDP-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol] (spontaneous) (1c) GDP-2-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol] + H2O = GDP-4-dehydro-3,6-dideoxy-α-D-mannose + NH3 (spontaneous) |
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For diagram of GDP-colitose biosynthesis, click here | |||||||||||||
Glossary: | GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose | ||||||||||||
Other name(s): | colD (gene name) | ||||||||||||
Systematic name: | GDP-4-dehydro-α-D-rhamnose 3-hydro-lyase | ||||||||||||
Comments: | This enzyme, involved in β-L-colitose biosynthesis, is a unique vitamin-B6-dependent enzyme. In the first step of catalysis, the bound pyridoxal phosphate (PLP) cafactor is transaminated to the pyridoxamine 5′-phosphate (PMP) form of vitamin B6, using L-glutamate as the amino group donor. The PMP cofactor then forms a Schiff base with the sugar substrate and the resulting adduct undergoes a 1,4-dehydration to eliminate the 3-OH group. Hydrolysis of the product from the enzyme restores the PLP cofactor and results in the release of an unstable enamine intermediate. This intermediate tautomerizes to form an imine form, which hydrolyses spontaneously, releasing ammonia and forming the final product. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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