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Your query returned 5 entries. Printable version
EC | 2.4.1.62 | ||||||||||||
Accepted name: | ganglioside galactosyltransferase | ||||||||||||
Reaction: | UDP-α-D-galactose + an N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide = UDP + a β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide | ||||||||||||
For diagram of ganglioside biosynthesis, click here | |||||||||||||
Glossary: | N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide = ganglioside GM2 a β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide = gangloside GM1a |
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Other name(s): | UDP-galactose—ceramide galactosyltransferase; uridine diphosphogalactose-ceramide galactosyltransferase; UDP galactose-LAC Tet-ceramide α-galactosyltransferase; UDP-galactose-GM2 galactosyltransferase; uridine diphosphogalactose-GM2 galactosyltransferase; uridine diphosphate D-galactose:glycolipid galactosyltransferase; UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase; UDP-galactose-GM2 ganglioside galactosyltransferase; GM1-synthase; UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine β-1,3-D-galactosyltransferase; UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1→4)-β-D-glucosyl-N-acylsphingosine 3-β-D-galactosyltransferase | ||||||||||||
Systematic name: | UDP-α-D-galactose:N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide 3-β-D-galactosyltransferase | ||||||||||||
Comments: | The substrate is also known as gangloside GM2, the product as gangloside GM1a | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37217-28-0 | ||||||||||||
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EC | 2.4.1.80 | ||||||||||||
Accepted name: | ceramide glucosyltransferase | ||||||||||||
Reaction: | UDP-α-D-glucose + an N-acylsphingosine = UDP + a β-D-glucosyl-N-acylsphingosine | ||||||||||||
For diagram of glycolipid biosynthesis, click here | |||||||||||||
Other name(s): | UDP-glucose:ceramide glucosyltransferase; ceramide:UDP-Glc glucosyltransferase; uridine diphosphoglucose-ceramide glucosyltransferase; ceramide:UDP-glucose glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase | ||||||||||||
Systematic name: | UDP-α-D-glucose:N-acylsphingosine β-D-glucosyltransferase (configuration-inverting) | ||||||||||||
Comments: | Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37237-44-8 | ||||||||||||
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EC | 3.2.1.45 | ||||||||||||
Accepted name: | glucosylceramidase | ||||||||||||
Reaction: | a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide | ||||||||||||
For diagram of glycolipid biosynthesis, click here | |||||||||||||
Glossary: | a ceramide = an N-acylsphingosine | ||||||||||||
Other name(s): | psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-β-glucosidase; β-D-glucocerebrosidase; glucosylcerebrosidase; β-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine β-glucosidase; glucosylsphingosine β-D-glucosidase | ||||||||||||
Systematic name: | D-glucosyl-N-acylsphingosine glucohydrolase | ||||||||||||
Comments: | Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37228-64-1 | ||||||||||||
References: |
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EC | 3.2.1.62 | ||||||||||||
Accepted name: | glycosylceramidase | ||||||||||||
Reaction: | (1) a β-D-glucosyl-N-acylsphingosine + H2O = a ceramide + β-D-glucose (2) a β-D-galactosyl-N-acylsphingosine + H2O = a ceramide + β-D-galactose (3) a flavonoid-O-β-D-glucoside + H2O = a flavonoid + β-D-glucose |
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For diagram of phloretin biosynthesis, click here and for diagram of glycolipid biosynthesis, click here | |||||||||||||
Glossary: | a ceramide = an N-acylsphingosine | ||||||||||||
Other name(s): | phlorizin hydrolase; phloretin-glucosidase; glycosyl ceramide glycosylhydrolase; cerebrosidase; phloridzin β-glucosidase; lactase-phlorizin hydrolase; phloridzin glucosidase; LPH (gene name); LCT (gene name); glycosyl-N-acylsphingosine glycohydrolase | ||||||||||||
Systematic name: | β-D-glucosyl-N-acylsphingosine glycohydrolase (configuration-retaining) | ||||||||||||
Comments: | The enzyme, found in the intestinal mucosa, hydrolyses β-D-glucosyl and β-D-galactosyl residues from a very broad range of substrates using a retaining mechanism. Characterized substrates include glucosyl- and galactosyl-ceramides [3], O3-, O4′ and O7-glucosylated flavonoids [6], and the 2′-O-glucosylated dihydrochalcone phlorizin [1]. The enzyme includes two glycosyl hydrolase domains, both belonging to the GH1 family. While one domain is responsible for the activity described here, the other catalyses the reaction of EC 3.2.1.108, lactase [4,5]. cf. EC 3.2.1.45, glucosylceramidase and EC 3.2.1.46, galactosylceramidase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-10-7 | ||||||||||||
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EC | 3.5.1.109 | ||||||||||||
Accepted name: | sphingomyelin deacylase | ||||||||||||
Reaction: | (1) an N-acyl-sphingosylphosphorylcholine + H2O = a fatty acid + sphingosylphosphorylcholine (2) a D-glucosyl-N-acylsphingosine + H2O = a fatty acid + D-glucosyl-sphingosine |
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Glossary: | sphingomyelin = N-acyl-sphingosylphosphorylcholine D-glucosyl-N-acylsphingosine = glucosylceramide |
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Other name(s): | SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase | ||||||||||||
Systematic name: | N-acyl-sphingosylphosphorylcholine amidohydrolase | ||||||||||||
Comments: | The enzyme is involved in the sphingolipid metabolism in the epidermis. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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