The Enzyme Database

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EC 1.1.1.57     
Accepted name: fructuronate reductase
Reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+
Other name(s): mannonate oxidoreductase; mannonic dehydrogenase; D-mannonate dehydrogenase; D-mannonate:NAD oxidoreductase
Systematic name: D-mannonate:NAD+ 5-oxidoreductase
Comments: Also reduces D-tagaturonate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9028-44-8
References:
1.  Hickman, J. and Ashwell, G. Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehyrogenases in Escherichia coli. J. Biol. Chem. 235 (1960) 1566–1570. [PMID: 14401695]
2.  Kilgore, W.W. and Starr, M.P. Catabolism of galacturonic and glucuronic acids by Erwinia carotovora. J. Biol. Chem. 234 (1959) 2227–2235. [PMID: 14409051]
[EC 1.1.1.57 created 1965]
 
 
EC 1.1.1.380     
Accepted name: L-gulonate 5-dehydrogenase
Reaction: L-gulonate + NAD+ = D-fructuronate + NADH + H+
Glossary: D-fructuronate = D-arabino-hexuronate
Systematic name: L-gulonate:NAD+ 5-oxidoreductase
Comments: The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Cooper, R.A. The pathway for L-gulonate catabolism in Escherichia coli K-12 and Salmonella typhimurium LT-2. FEBS Lett. 115 (1980) 63–67. [DOI] [PMID: 6993236]
2.  Wichelecki, D.J., Vendiola, J.A., Jones, A.M., Al-Obaidi, N., Almo, S.C. and Gerlt, J.A. Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate. Biochemistry 53 (2014) 5692–5699. [DOI] [PMID: 25145794]
[EC 1.1.1.380 created 2014]
 
 
EC 5.1.2.7     
Accepted name: tagaturonate epimerase
Reaction: D-tagaturonate = D-fructuronate
Other name(s): fructuronate epimerase; tagaturonate/fructuronate epimerase; UxaE
Systematic name: D-tagaturonate 3-epimerase
Comments: The enzyme, present in bacteria, is involved in a degradation pathway of D-galacturonate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Rodionova, I.A., Scott, D.A., Grishin, N.V., Osterman, A.L. and Rodionov, D.A. Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima. Environ. Microbiol. 14 (2012) 2920–2934. [DOI] [PMID: 22925190]
[EC 5.1.2.7 created 2017]
 
 
EC 5.3.1.12     
Accepted name: glucuronate isomerase
Reaction: D-glucuronate = D-fructuronate
Other name(s): uronic isomerase; uronate isomerase; D-glucuronate isomerase; uronic acid isomerase; D-glucuronate ketol-isomerase
Systematic name: D-glucuronate aldose-ketose-isomerase
Comments: Also converts D-galacturonate to D-tagaturonate.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-87-4
References:
1.  Ashwell, G., Wahba, A.J. and Hickman, J. Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli. J. Biol. Chem. 235 (1960) 1559–1565. [PMID: 13794771]
2.  Kilgore, W.W. and Starr, M.P. Catabolism of galacturonic and glucuronic acids by Erwinia carotovora. J. Biol. Chem. 234 (1959) 2227–2235. [PMID: 14409051]
[EC 5.3.1.12 created 1961]
 
 


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