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Your query returned 2 entries. Printable version
EC | 3.1.4.56 | ||
Accepted name: | 7,8-dihydroneopterin 2′,3′-cyclic phosphate phosphodiesterase | ||
Reaction: | (1) 7,8-dihydroneopterin 2′,3′-cyclic phosphate + H2O = 7,8-dihydroneopterin 3′-phosphate (2) 7,8-dihydroneopterin 2′,3′-cyclic phosphate + H2O = 7,8-dihydroneopterin 2′-phosphate |
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For diagram of methanopterin biosynthesis (part 1), click here | |||
Glossary: | 7,8-dihydroneopterin 2′,3′-cyclic phosphate = 2-amino-6-{(S)-hydroxy[(4R)-2-hydroxy-2-oxido-1,3,2-dioxaphospholan-4-yl]methyl}-7,8-dihydropteridin-4(1H)-one = 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-4(1H)-pteridinone 1,2-cyclic phosphate 7,8-dihydroeopterin 3′-phosphate = (2R,3S)-3-(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropyl phosphate 7,8-dihydroneopterin 2′-phosphate = (1S,2R)-1-(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)-1,3-dihydroxypropan-2-yl phosphate |
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Other name(s): | MptB | ||
Systematic name: | 7,8-dihydroneopterin 2′,3′-cyclic phosphate 2′/3′-phosphodiesterase | ||
Comments: | Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2′,3′-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2′-phosphate and 7,8-dihydroneopterin 3′-phosphate at a ratio of 4:1. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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EC | 3.5.4.39 | ||
Accepted name: | GTP cyclohydrolase IV | ||
Reaction: | GTP + H2O = 7,8-dihydroneopterin 2′,3′-cyclic phosphate + formate + diphosphate | ||
For diagram of methanopterin biosynthesis (part 1), click here | |||
Glossary: | 7,8-dihydroneopterin 2′,3′-cyclic phosphate = 2-amino-6-{(S)-hydroxy[(4R)-2-hydroxy-2-oxido-1,3,2-dioxaphospholan-4-yl]methyl}-7,8-dihydropteridin-4(1H)-one = 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-4(1H)-pteridinone 1,2-cyclic phosphate |
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Other name(s): | MptA; GTP cyclohydrolase MptA | ||
Systematic name: | GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing) | ||
Comments: | Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29). | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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