ExplorEnz: Search Results

Your query returned 2 entries. Printable version

3.5.2.17

Accepted name:

hydroxyisourate hydrolase

Reaction:

5-hydroxyisourate + H₂O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate

For diagram of AMP catabolism, click here

Other name(s):

HIUHase; 5-hydroxyisourate hydrolase

Systematic name:

5-hydroxyisourate amidohydrolase

Comments:

The reaction is the first stage in the conversion of 5-hydroxyisourate into S-allantoin. This reaction will also occur spontaneously but more slowly.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 255885-20-2

References:

1.	Raychaudhuri, A. and Tipton, P.A. A familiar motif in a new context: the catalytic mechanism of hydroxyisourate hydrolase. Biochemistry 42 (2003) 6848–6852. [DOI] [PMID: 12779339]
2.	Raychaudhuri, A. and Tipton, P.A. Cloning and expression of the gene for soybean hydroxyisourate hydrolase. Localization and implications for function and mechanism. Plant Physiol. 130 (2002) 2061–2068. [DOI] [PMID: 12481089]
3.	Sarma, A.D., Serfozo, P., Kahn, K. and Tipton, P.A. Identification and purification of hydroxyisourate hydrolase, a novel ureide-metabolizing enzyme. J. Biol. Chem. 274 (1999) 33863–33865. [DOI] [PMID: 10567345]

[EC 3.5.2.17 created 2004]

4.1.1.97

Accepted name:

2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Reaction:

5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)-allantoin + CO₂

For diagram of AMP catabolism, click here

Glossary:

5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline

Other name(s):

OHCU decarboxylase; hpxQ (gene name); PRHOXNB (gene name)

Systematic name:

5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate carboxy-lyase [(S)-allantoin-forming]

Comments:

This enzyme is part of the pathway from urate to (S)-allantoin, which is present in bacteria, plants and animals (but not in humans).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Ramazzina, I., Folli, C., Secchi, A., Berni, R. and Percudani, R. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Nat. Chem. Biol. 2 (2006) 144–148. [DOI] [PMID: 16462750]
2.	Cendron, L., Berni, R., Folli, C., Ramazzina, I., Percudani, R. and Zanotti, G. The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation. J. Biol. Chem. 282 (2007) 18182–18189. [DOI] [PMID: 17428786]
3.	Kim, K., Park, J. and Rhee, S. Structural and functional basis for (S)-allantoin formation in the ureide pathway. J. Biol. Chem. 282 (2007) 23457–23464. [DOI] [PMID: 17567580]
4.	French, J.B. and Ealick, S.E. Structural and mechanistic studies on Klebsiella pneumoniae 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. J. Biol. Chem. 285 (2010) 35446–35454. [DOI] [PMID: 20826786]

[EC 4.1.1.97 created 2014]