| EC |
1.2.1.83 |
| Accepted name: |
3-succinoylsemialdehyde-pyridine dehydrogenase |
| Reaction: |
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ |
| Glossary: |
4-oxo-4-(pyridin-3-yl)butanal = 3-succinoylsemialdehyde-pyridine
4-oxo-4-(3-pyridyl)-butanoate = 3-succinoyl-pyridine |
| Systematic name: |
4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase |
| Comments: |
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway. |
| References: |
| 1. |
Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine. Appl. Environ. Microbiol. 78 (2012) 2154–2160. [PMID: 22267672] |
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| [EC 1.2.1.83 created 2012] |
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| EC |
1.4.3.24 |
| Accepted name: |
pseudooxynicotine oxidase |
| Reaction: |
4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H2O + O2 = 4-oxo-4-(pyridin-3-yl)butanal + methylamine + H2O2 |
| Glossary: |
4-(methylamino)-1-(pyridin-3-yl)butan-1-one = pseudooxynicotine
4-oxo-4-(pyridin-3-yl)butanal = 3-succinoylsemialdehyde-pyridine |
| Systematic name: |
4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing) |
| Comments: |
Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacterium Pseudomonas sp. HZN6, is involved the nicotine degradation. |
| References: |
| 1. |
Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine. Appl. Environ. Microbiol. 78 (2012) 2154–2160. [PMID: 22267672] |
|
| [EC 1.4.3.24 created 2012] |
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