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Your query returned 2 entries. Printable version
EC | 1.14.11.81 | ||||||||||||||||||||
Accepted name: | (–)-cyclopenine synthase | ||||||||||||||||||||
Reaction: | (1) cyclopeptine + 2-oxoglutarate + O2 = dehydrocyclopeptine + succinate + CO2 + H2O (2) dehydrocyclopeptine + 2-oxoglutarate + O2 = (–)-cyclopenine + succinate + CO2 |
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For diagram of cyclopeptine, cyclopenine and viridicatin biosynthesis, click here | |||||||||||||||||||||
Glossary: | cyclopeptine = (3S)-3-benzyl-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (–)-cyclopenine = (3S,3′R)-4-methyl-3′-phenyl-1H-spiro[1,4-benzodiazepine-3,2′-oxirane]-2,5-dione |
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Other name(s): | asqJ (gene name) | ||||||||||||||||||||
Systematic name: | cyclopeptine,2-oxoglutarate:oxygen oxidoreductase ((–)-cyclopenine-forming) | ||||||||||||||||||||
Comments: | This fungal enzyme is involved in the biosynthesis of quinolone compounds. it catalyses two oxidation reactions: the first reaction results in a desaturation; the second reaction is a monooxygenation of the double bond, forming an epoxide. The enzyme is also active with 4′-methoxycyclopeptine. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||
References: |
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EC | 6.3.2.40 | ||||||||||||||||||||
Accepted name: | cyclopeptine synthase | ||||||||||||||||||||
Reaction: | 2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine | ||||||||||||||||||||
For diagram of cyclopeptine, cyclopenine and viridicatin biosynthesis, click here | |||||||||||||||||||||
Glossary: | cyclopeptine = (3S)-3-benzyl-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione 4′-methoxycyclopeptine = (3S)-3-(4-methoxybenzyl)-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione |
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Systematic name: | S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine-forming) | ||||||||||||||||||||
Comments: | Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in several fungi species. The enzyme is a non-ribosomal peptide synthase. It is also active with O-methyl-L-tyrosine forming 4′-methoxycyclopeptine. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||
References: |
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