The Enzyme Database

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Accepted name: maleylpyruvate hydrolase
Reaction: 3-maleylpyruvate + H2O = maleate + pyruvate
Glossary: 3-maleylpyruvate = (2Z)-4,6-dioxohept-2-enedioate
Other name(s): hbzF (gene name)
Systematic name: (2Z)-4,6-dioxohept-2-enedioate acylhydrolase
Comments: The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC, acylpyruvate hydrolase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Hopper, D.J., Chapman, P.J. and Dagley, S. The enzymic degradation of alkyl-substituted gentisates, maleates and malates. Biochem. J. 122 (1971) 29–40. [PMID: 5124802]
2.  Bayly, R.C., Chapman, P.J., Dagley, S. and Di Berardino, D. Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate hydrolase from Pseudomonas alcaligenes. J. Bacteriol. 143 (1980) 70–77. [PMID: 7400101]
3.  Liu, K., Liu, T.T. and Zhou, N.Y. HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867. Appl. Environ. Microbiol. 79 (2013) 1044–1047. [DOI] [PMID: 23204427]
[EC created 2016]
Accepted name: maleylpyruvate isomerase
Reaction: 3-maleylpyruvate = 3-fumarylpyruvate
Systematic name: 3-maleylpyruvate cis-trans-isomerase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9023-77-2
1.  Lack, L. Enzymic cis-trans isomerization of maleylpyruvic acid. J. Biol. Chem. 236 (1961) 2835–2840. [PMID: 14461395]
[EC created 1965]

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