EC |
1.1.3.48 |
Accepted name: |
3-deoxy-α-D-manno-octulosonate 8-oxidase |
Reaction: |
3-deoxy-α-D-manno-octulopyranosonate + O2 = 3,8-dideoxy-8-oxo-α-D-manno-octulosonate + H2O2 |
Glossary: |
3-deoxy-α-D-manno-octulosonate = Kdo
3,8-dideoxy-8-oxo-α-D-manno-octulosonate = (2R,4R,5R,6S)-2,4,5-trihydroxy-6-[(1S)-1-hydroxy-2-oxoethyl]oxane-2-carboxylate |
Other name(s): |
kdnB (gene name) |
Systematic name: |
3-deoxy-α-D-manno-octulopyranosonate:oxygen 8-oxidoreductase |
Comments: |
The enzyme, characterized from the bacterium Shewanella oneidensis, is involved in the formation of 8-amino-3,8-dideoxy-α-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 2.6.1.109, 8-amino-3,8-dideoxy-α-D-manno-octulosonate transaminase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Gattis, S.G., Chung, H.S., Trent, M.S. and Raetz, C.R. The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. J. Biol. Chem. 288 (2013) 9216–9225. [DOI] [PMID: 23413030] |
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[EC 1.1.3.48 created 2015] |
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EC |
2.6.1.109 |
Accepted name: |
8-amino-3,8-dideoxy-α-D-manno-octulosonate transaminase |
Reaction: |
8-amino-3,8-dideoxy-α-D-manno-octulosonate + 2-oxoglutarate = 8-dehydro-3-deoxy-α-D-manno-octulosonate + L-glutamate |
Glossary: |
3-deoxy-α-D-manno-octulosonate = Kdo
8-dehydro-3-deoxy-α-D-manno-octulosonate = (2R,4R,5R,6S)-2,4,5-trihydroxy-6-[(1S)-1-hydroxy-2-oxoethyl]oxane-2-carboxylate |
Other name(s): |
kdnA (gene name) |
Systematic name: |
8-amino-3,8-dideoxy-α-D-manno-octulosonate:2-oxoglutarate aminotransferase |
Comments: |
The enzyme, characterized from the bacterium Shewanella oneidensis, forms 8-amino-3,8-dideoxy-α-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 1.1.3.48, 3-deoxy-α-D-manno-octulosonate 8-oxidase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Gattis, S.G., Chung, H.S., Trent, M.S. and Raetz, C.R. The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. J. Biol. Chem. 288 (2013) 9216–9225. [DOI] [PMID: 23413030] |
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[EC 2.6.1.109 created 2015] |
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EC |
2.7.7.90 |
Accepted name: |
8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase |
Reaction: |
CTP + 8-amino-3,8-dideoxy-α-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-α-D-manno-octulosonate |
Other name(s): |
kdsB (gene name, ambiguous) |
Systematic name: |
CTP:8-amino-3,8-dideoxy-α-D-manno-octulosonate cytidylyltransferase |
Comments: |
The enzyme, characterized from the bacterium Shewanella oneidensis MR-1, acts on the 8-aminated from of 3-deoxy-α-D-manno-octulosonate (Kdo). cf. EC 2.7.7.38, 3-deoxy-manno-octulosonate cytidylyltransferase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Gattis, S.G., Chung, H.S., Trent, M.S. and Raetz, C.R. The origin of 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) in the lipopolysaccharide of Shewanella oneidensis. J. Biol. Chem. 288 (2013) 9216–9225. [DOI] [PMID: 23413030] |
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[EC 2.7.7.90 created 2016] |
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