| EC |
3.1.4.17 |
| Accepted name: |
3′,5′-cyclic-nucleotide phosphodiesterase |
| Reaction: |
nucleoside 3′,5′-cyclic phosphate + H2O = nucleoside 5′-phosphate |
| Other name(s): |
cyclic 3′,5′-mononucleotide phosphodiesterase; PDE; cyclic 3′,5′-nucleotide phosphodiesterase; cyclic 3′,5′-phosphodiesterase; 3′,5′-nucleotide phosphodiesterase; 3′:5′-cyclic nucleotide 5′-nucleotidohydrolase; 3′,5′-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3′, 5′-cyclic nucleoside monophosphate phosphodiesterase; 3′: 5′-monophosphate phosphodiesterase (cyclic CMP); cytidine 3′:5′-monophosphate phosphodiesterase (cyclic CMP); cyclic 3′,5-nucleotide monophosphate phosphodiesterase; nucleoside 3′,5′-cyclic phosphate diesterase; nucleoside-3′,5-monophosphate phosphodiesterase |
| Systematic name: |
3′,5′-cyclic-nucleotide 5′-nucleotidohydrolase |
| Comments: |
Acts on 3′,5′-cyclic AMP, 3′,5′-cyclic dAMP, 3′,5′-cyclic IMP, 3′,5′-cyclic GMP and 3′,5′-cyclic CMP. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9040-59-9 |
| References: |
| 1. |
Fischer, U. and Amrhein, N. Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii. Biochim. Biophys. Acta 341 (1974) 412–420. [DOI] [PMID: 4365506] |
| 2. |
Nair, K.G. Purification and properties of 3′,5′-cyclic nucleotide phosphodiesterase from dog heart. Biochemistry 5 (1966) 150–157. [PMID: 4287216] |
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| [EC 3.1.4.17 created 1972, modified 1976] |
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| EC |
4.6.1.6 |
| Accepted name: |
cytidylate cyclase |
| Reaction: |
CTP = 3′,5′-cyclic CMP + diphosphate |
| Glossary: |
3′,5′-cyclic CMP = cCMP
cytidylate = CMP |
| Other name(s): |
3′,5′-cyclic-CMP synthase; cytidylyl cyclase; cytidyl cyclase; CTP diphosphate-lyase (cyclizing); pycC (gene name) (ambiguous) |
| Systematic name: |
CTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-CMP-forming) |
| Comments: |
In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 65357-82-6 |
| References: |
| 1. |
Cech, S.Y. and Ignarro, L.J. Cytidine 3′,5′-monophosphate (cyclic CMP) formation by homogenates of mouse liver. Biochem. Biophys. Res. Commun. 80 (1978) 119–125. [DOI] [PMID: 23778] |
| 2. |
Newton, R.P., Salih, S.G., Hakeem, N.A., Kingston, E.E. and Beynon, J.H. 3′,5′-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian tissues. Biochem. Soc. Trans. 13 (1985) 1134–1135. [DOI] |
| 3. |
Tal, N., Morehouse, B.R., Millman, A., Stokar-Avihail, A., Avraham, C., Fedorenko, T., Yirmiya, E., Herbst, E., Brandis, A., Mehlman, T., Oppenheimer-Shaanan, Y., Keszei, A.FA., Shao, S., Amitai, G., Kranzusch, P.J. and Sorek, R. Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell 184 (2021) 5728–5739.e16. [DOI] [PMID: 34644530] |
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| [EC 4.6.1.6 created 1989] |
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