The Enzyme Database

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EC 2.3.1.272     
Accepted name: 2-acetylphloroglucinol acetyltransferase
Reaction: 2 2-acetylphloroglucinol = 2,4-diacetylphloroglucinol + phloroglucinol
Glossary: phloroglucinol = benzene-1,3,5-triol
Other name(s): MAPG ATase
Systematic name: 2-acetylphloroglucinol C-acetyltransferase
Comments: The enzyme from the bacterium Pseudomonas sp. YGJ3 is composed of three subunits named PhlA, PhlB and PhlC. Production of 2,4-diacetylphloroglucinol, which has antibiotic activity, is strongly inhibited by chloride ions.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Hayashi, A., Saitou, H., Mori, T., Matano, I., Sugisaki, H. and Maruyama, K. Molecular and catalytic properties of monoacetylphloroglucinol acetyltransferase from Pseudomonas sp. YGJ3. Biosci. Biotechnol. Biochem. 76 (2012) 559–566. [DOI] [PMID: 22451400]
[EC 2.3.1.272 created 2018]
 
 
EC 3.7.1.24     
Accepted name: 2,4-diacetylphloroglucinol hydrolase
Reaction: 2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate
Glossary: phloroglucinol = benzene-1,3,5-triol
2,4-diacetylphloroglucinol = 1,1′-(2,4,6-trihydroxybenzene-1,3-diyl)diethan-1-one
Other name(s): PhlG
Systematic name: 2,4-diacetylphloroglucinol acetylhydrolase
Comments: Requires Zn2+. Isolated from the bacteria Pseudomonas fluorescens, Pseudomonas sp. YGJ3 and Mycobacterium abscessus 103. It reduces the antibiotic activity of 2,4-diacetylphloroglucinol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
References:
1.  Bottiglieri, M. and Keel, C. Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0. Appl. Environ. Microbiol. 72 (2006) 418–427. [PMID: 16391073]
2.  He, Y.X., Huang, L., Xue, Y., Fei, X., Teng, Y.B., Rubin-Pitel, S.B., Zhao, H. and Zhou, C.Z. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J. Biol. Chem. 285 (2010) 4603–4611. [PMID: 20018877]
3.  Saitou, H., Watanabe, M. and Maruyama, K. Molecular and catalytic properties of 2,4-diacetylphloroglucinol hydrolase (PhlG) from Pseudomonas sp. YGJ3. Biosci. Biotechnol. Biochem. 76 (2012) 1239–1241. [PMID: 22790955]
4.  Zhang, Z., Jiang, Y.L., Wu, Y. and He, Y.X. Crystallization and preliminary X-ray diffraction analysis of a putative carbon-carbon bond hydrolase from Mycobacterium abscessus 103. Acta Crystallogr. F Struct. Biol. Commun. 71 (2015) 239–242. [PMID: 25664803]
[EC 3.7.1.24 created 2019]
 
 


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