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Your query returned 48 entries. Printable version
EC | 2.5.1.70 | Relevance: 100% | ||||||||||||
Accepted name: | naringenin 8-dimethylallyltransferase | |||||||||||||
Reaction: | prenyl diphosphate + (–)-(2S)-naringenin = diphosphate + sophoraflavanone B | |||||||||||||
For diagram of sophoraflavanone G biosynthesis, click here | ||||||||||||||
Glossary: | dimethylallyl = prenyl = 3-methylbut-2-en-1-yl (–)-(2S)-naringenin = (–)-(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one sophoraflavanone B = (–)-(2S)-8-prenylnaringenin = (–)-(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-2,3-dihydrochromen-4-one |
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Other name(s): | N8DT; dimethylallyl-diphosphate:naringenin 8-dimethylallyltransferase | |||||||||||||
Systematic name: | prenyl-diphosphate:naringenin 8-prenyltransferase | |||||||||||||
Comments: | Requires Mg2+. This membrane-bound protein is located in the plastids [2]. In addition to naringenin, the enzyme can prenylate several other flavanones at the C-8 position, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2′-hydroxylase) and EC 2.5.1.71 (leachianone-G 2′′-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 2.1.1.232 | Relevance: 99.6% | ||||||||||||
Accepted name: | naringenin 7-O-methyltransferase | |||||||||||||
Reaction: | S-adenosyl-L-methionine + (2S)-naringenin = S-adenosyl-L-homocysteine + (2S)-sakuranetin | |||||||||||||
For diagram of naringenin methyl ethers biosynthesis, click here | ||||||||||||||
Glossary: | (2S)-naringenin = (2S)-5,7,4′-trihydroxyflavan-4-one (2S)-sakuranetin = (2S)-5,4′-dihydroxy-7-methoxyflavan-4-one |
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Other name(s): | NOMT | |||||||||||||
Systematic name: | S-adenosyl-L-methionine:(2S)-5,7,4′-trihydroxyflavanone 7-O-methyltransferase | |||||||||||||
Comments: | The enzyme is involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of the plant Oryza sativa (Asian rice) against pathogen attack. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 2.1.1.231 | Relevance: 87.7% | ||||||||||||
Accepted name: | flavonoid 4′-O-methyltransferase | |||||||||||||
Reaction: | S-adenosyl-L-methionine + a 4′-hydroxyflavanone = S-adenosyl-L-homocysteine + a 4′-methoxyflavanone | |||||||||||||
For diagram of naringenin methyl ethers biosynthesis, click here | ||||||||||||||
Glossary: | naringenin = 4′,5,7-trihydroxyflavan-4-one | |||||||||||||
Other name(s): | SOMT-2; 4′-hydroxyisoflavone methyltransferase | |||||||||||||
Systematic name: | S-adenosyl-L-methionine:flavonoid 4′-O-methyltransferase | |||||||||||||
Comments: | The enzyme catalyses the 4′-methylation of naringenin. In vitro it catalyses the 4′-methylation of apigenin, quercetin, daidzein and genistein. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 2.4.1.185 | Relevance: 86.7% | ||||||||||||
Accepted name: | flavanone 7-O-β-glucosyltransferase | |||||||||||||
Reaction: | UDP-glucose + a flavanone = UDP + a flavanone 7-O-β-D-glucoside | |||||||||||||
For diagram of the biosynthesis of naringenin derivatives, click here | ||||||||||||||
Other name(s): | uridine diphosphoglucose-flavanone 7-O-glucosyltransferase; naringenin 7-O-glucosyltransferase; hesperetin 7-O-glucosyl-transferase | |||||||||||||
Systematic name: | UDP-glucose:flavanone 7-O-β-D-glucosyltransferase | |||||||||||||
Comments: | Naringenin and hesperetin can act as acceptors. No action on flavones or flavonols. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 125752-73-0 | |||||||||||||
References: |
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EC | 1.14.11.9 | Relevance: 80.5% | ||||||||||||
Accepted name: | flavanone 3-dioxygenase | |||||||||||||
Reaction: | a (2S)-flavan-4-one + 2-oxoglutarate + O2 = a (2R,3R)-dihydroflavonol + succinate + CO2 | |||||||||||||
For diagram of flavonoid biosynthesis, click here and for diagram of naringenin derivatives biosynthesis, click here | ||||||||||||||
Other name(s): | naringenin 3-hydroxylase; flavanone 3-hydroxylase; flavanone 3β-hydroxylase; flavanone synthase I; (2S)-flavanone 3-hydroxylase; naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating); F3H; flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | |||||||||||||
Systematic name: | (2S)-flavan-4-one,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) | |||||||||||||
Comments: | Requires Fe2+ and ascorbate. This plant enzyme catalyses an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins. Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)-dihydrotricetin and (2S)-pinocembrin. Some enzymes are bifuctional and also catalyse EC 1.14.20.6, flavonol synthase. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 75991-43-4 | |||||||||||||
References: |
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EC | 1.1.1.234 | Relevance: 78.8% | ||||||||||||
Accepted name: | flavanone 4-reductase | |||||||||||||
Reaction: | (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH + H+ | |||||||||||||
For diagram of the biosynthesis of naringenin derivatives, click here | ||||||||||||||
Systematic name: | (2S)-flavan-4-ol:NADP+ 4-oxidoreductase | |||||||||||||
Comments: | Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 115232-53-6 | |||||||||||||
References: |
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EC | 2.3.1.74 | Relevance: 68.5% | ||||||||||||
Accepted name: | chalcone synthase | |||||||||||||
Reaction: | 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 | |||||||||||||
For diagram of chalcone and stilbene biosynthesis, click here | ||||||||||||||
Glossary: | phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one | |||||||||||||
Other name(s): | naringenin-chalcone synthase; flavanone synthase; 6′-deoxychalcone synthase; chalcone synthetase; DOCS; CHS | |||||||||||||
Systematic name: | malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) | |||||||||||||
Comments: | The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56803-04-4 | |||||||||||||
References: |
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EC | 1.14.13.21 | |||||||||||||
Transferred entry: | flavonoid 3′-monooxygenase. Now EC 1.14.14.82, flavonoid 3′-monooxygenase. | |||||||||||||
EC | 1.14.11.23 | |||||||||||||
Transferred entry: | flavonol synthase. Now EC 1.14.20.6, flavonol synthase | |||||||||||||
EC | 1.14.13.88 | |||||||||||||
Transferred entry: | flavanoid 3,5-hydroxylase. Now EC 1.14.14.81, flavanoid 3,5-hydroxylase | |||||||||||||
EC | 1.14.20.6 | Relevance: 65% | ||||||||||||
Accepted name: | flavonol synthase | |||||||||||||
Reaction: | a dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O | |||||||||||||
For diagram of flavonoid biosynthesis, click here, for diagram of kaempferol biosynthesis, click here and for diagram of myricetin biosynthesis, click here | ||||||||||||||
Other name(s): | FLS (gene name) | |||||||||||||
Systematic name: | dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase | |||||||||||||
Comments: | In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from Citrus unshiu (satsuma mandarin) also has a non-specific activity that trans-hydroxylates the flavanones (2S)-naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively [2]. Requires Fe2+. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 146359-76-4 | |||||||||||||
References: |
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EC | 2.1.1.75 | Relevance: 64.2% | ||||||||||||
Accepted name: | apigenin 4′-O-methyltransferase | |||||||||||||
Reaction: | S-adenosyl-L-methionine + apigenin = S-adenosyl-L-homocysteine + acacetin | |||||||||||||
For diagram of apigenin derivatives biosynthesis, click here | ||||||||||||||
Glossary: | apigenin = 4′,5,7-trihydroxyflavone acacetin = 4′-methoxy-5,7-dihydroxyflavone naringenin = 4′,5,7-trihydroxyflavan-4-one |
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Other name(s): | flavonoid O-methyltransferase; flavonoid methyltransferase; S-adenosyl-L-methionine:5,7,4′-trihydroxyflavone 4′-O-methyltransferase | |||||||||||||
Systematic name: | S-adenosyl-L-methionine:apigenin 4′-O-methyltransferase | |||||||||||||
Comments: | Converts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 118251-36-8 | |||||||||||||
References: |
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EC | 2.4.1.286 | Relevance: 62.9% | ||||||||||||
Accepted name: | chalcone 4′-O-glucosyltransferase | |||||||||||||
Reaction: | (1) UDP-α-D-glucose + naringenin chalcone = UDP + 2′,4,4′,6′-tetrahydroxychalcone 4′-O-β-D-glucoside (2) UDP-α-D-glucose + 2′,3,4,4′,6′-pentahydroxychalcone = UDP + 2′,3,4,4′,6′-pentahydroxychalcone 4′-O-β-D-glucoside |
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For diagram of aureusidin biosynthesis, click here | ||||||||||||||
Glossary: | naringenin chalcone = 2′,4,4′,6′-tetrahydroxychalcone = 3-(4-hydroxyphemyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one |
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Other name(s): | 4′CGT | |||||||||||||
Systematic name: | UDP-α-D-glucose:2′,4,4′,6′-tetrahydroxychalcone 4′-O-β-D-glucosyltransferase | |||||||||||||
Comments: | Isolated from the plant Antirrhinum majus (snapdragon). Involved in the biosynthesis of aurones, plant flavonoids that provide yellow color to the flowers. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.14.81 | Relevance: 60% | ||||||||||||
Accepted name: | flavanoid 3′,5′-hydroxylase | |||||||||||||
Reaction: | a flavanone + 2 [reduced NADPH—hemoprotein reductase] + 2 O2 = a 3′,5′-dihydroxyflavanone + 2 [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction) (1a) a flavanone + [reduced NADPH—hemoprotein reductase] + O2 = a 3′-hydroxyflavanone + [oxidized NADPH—hemoprotein reductase] + H2O (1b) a 3′-hydroxyflavanone + [reduced NADPH—hemoprotein reductase] + O2 = a 3′,5′-dihydroxyflavanone + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of myricetin biosynthesis, click here, for diagram of the biosynthesis of naringenin derivatives, click here and for diagram of flavonoid biosynthesis, click here | ||||||||||||||
Other name(s): | flavonoid 3′,5′-hydroxylase | |||||||||||||
Systematic name: | flavanone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3′,5′-dihydroxylating) | |||||||||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein found in plants. The 3′,5′-dihydroxyflavanone is formed via the 3′-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4′-trihydroxyflavanone (naringenin) at either the 3′ position to form eriodictyol or at both the 3′ and 5′ positions to form 5,7,3′,4′,5′-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3′,4′-pentahydroxyflavanone (taxifolin) at the 5′ position, forming ampelopsin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 94047-23-1 | |||||||||||||
References: |
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EC | 1.14.14.82 | Relevance: 59.8% | ||||||||||||
Accepted name: | flavonoid 3′-monooxygenase | |||||||||||||
Reaction: | a flavonoid + [reduced NADPH—hemoprotein reductase] + O2 = a 3′-hydroxyflavonoid + [oxidized NADPH—hemoprotein reductase] + H2O | |||||||||||||
For diagram of flavonoid biosynthesis, click here and for diagram of the biosynthesis of naringenin derivatives, click here | ||||||||||||||
Other name(s): | CYP75B1 (gene name); flavonoid 3′-hydroxylase; flavonoid 3-hydroxylase (incorrect); NADPH:flavonoid-3′-hydroxylase (incorrect); flavonoid 3-monooxygenase (incorrect) | |||||||||||||
Systematic name: | flavonoid,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3′-hydroxylating) | |||||||||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein found in plants. Acts on a number of flavonoids, including the flavanone naringenin and the flavone apigenin. Does not act on 4-coumarate or 4-coumaroyl-CoA. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 75991-44-5 | |||||||||||||
References: |
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EC | 2.3.1.156 | Relevance: 59.7% | ||||||||||||
Accepted name: | phloroisovalerophenone synthase | |||||||||||||
Reaction: | (1) isovaleryl-CoA + 3 malonyl-CoA = 4 CoA + 3 CO2 + phlorisovalerophenone (2) isobutyryl-CoA + 3 malonyl-CoA = 4 CoA + 3 CO2 + phlorisobutyrophenone |
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For diagram of polyketides biosynthesis, click here | ||||||||||||||
Glossary: | phlorisobutyrophenone = 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one phlorisovalerophenone = 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one |
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Other name(s): | valerophenone synthase; 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase; acylphloroglucinol synthase; isovaleryl-CoA:malonyl-CoA acyltransferase | |||||||||||||
Systematic name: | acyl-CoA:malonyl-CoA acyltransferase | |||||||||||||
Comments: | Closely related to EC 2.3.1.74, naringenin-chalcone synthase. Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone. The products are intermediates in the biosynthesis of the bitter acids in hops (Humulus lupulus) and glucosides in strawberry (Fragaria X ananassa). It is also able to generate naringenin chalcone from 4-coumaroyl-CoA. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 1.14.13.136 | |||||||||||||
Transferred entry: | 2-hydroxyisoflavanone synthase. Now EC 1.14.14.87, 2-hydroxyisoflavanone synthase | |||||||||||||
EC | 1.14.14.87 | Relevance: 56% | ||||||||||||
Accepted name: | 2-hydroxyisoflavanone synthase | |||||||||||||
Reaction: | (1) liquiritigenin + O2 + [reduced NADPH—hemoprotein reductase] = 2,4′,7-trihydroxyisoflavanone + H2O + [oxidized NADPH—hemoprotein reductase] (2) (2S)-naringenin + O2 + [reduced NADPH—hemoprotein reductase] = 2,4′,5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH—hemoprotein reductase] |
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For diagram of daidzein biosynthesis, click here | ||||||||||||||
Glossary: | liquiritigenin = 4′,7-dihydroxyflavanone (2S)-naringenin = 4′,5,7-dihydroxyflavanone 2,4′,5,7-tetrahydroxyisoflavanone = 2-hydroxy-2,3-dihydrogenistein |
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Other name(s): | CYP93C; IFS; isoflavonoid synthase | |||||||||||||
Systematic name: | liquiritigenin, [reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (hydroxylating, aryl migration) | |||||||||||||
Comments: | A cytochrome P-450 (heme thiolate) protein found in plants. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | |||||||||||||
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EC | 2.5.1.136 | Relevance: 55.8% | ||||||||||||
Accepted name: | 2-acylphloroglucinol 4-prenyltransferase | |||||||||||||
Reaction: | prenyl diphosphate + a 2-acylphloroglucinol = diphosphate + a 2-acyl-4-prenylphloroglucinol | |||||||||||||
Glossary: | naringenin chalcone = 2′,4,4′,6′-tetrahydroxychalcone = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one phlorisovalerophenone = 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one |
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Other name(s): | PT-1 (gene name); PT1L (gene name); aromatic prenyltransferase (ambiguous); dimethylallyl-diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase | |||||||||||||
Systematic name: | prenyl-diphosphate:2-acylphloroglucinol 4-prenyltransferase | |||||||||||||
Comments: | The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC 2.5.1.137, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.14.142 | Relevance: 55.7% | ||||||||||||
Accepted name: | 8-dimethylallylnaringenin 2′-hydroxylase | |||||||||||||
Reaction: | sophoraflavanone B + [reduced NADPH—hemoprotein reductase] + O2 = leachianone G + [oxidized NADPH—hemoprotein reductase] + H2O | |||||||||||||
For diagram of sophoraflavanone G biosynthesis, click here | ||||||||||||||
Glossary: | dimethylallyl = prenyl = 3-methylbut-2-en-1-yl lavandulyl = 5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl leachianone G = (–)-(2S)-2′-hydroxy-8-prenylnaringenin = (–)-(2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one naringenin = 5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one sophoraflavanone B = (–)-(2S)-8-prenylnaringenin = (–)-(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one |
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Other name(s): | 8-DMAN 2′-hydroxylase | |||||||||||||
Systematic name: | sophoraflavanone-B,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2′-hydroxylating) | |||||||||||||
Comments: | A membrane-bound cytochrome P-450 (heme-thiolate) protein that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2′′-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone G biosynthetic pathway. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 5.3.3.11 | Relevance: 52.7% | ||||||||||||
Accepted name: | isopiperitenone Δ-isomerase | |||||||||||||
Reaction: | isopiperitenone = piperitenone | |||||||||||||
For diagram of (–)-carvone, perillyl aldehyde and pulegone biosynthesis, click here | ||||||||||||||
Systematic name: | isopiperitenone Δ8-Δ4-isomerase | |||||||||||||
Comments: | Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 96595-07-2 | |||||||||||||
References: |
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EC | 2.4.1.236 | Relevance: 52.6% | ||||||||||||
Accepted name: | flavanone 7-O-glucoside 2′′-O-β-L-rhamnosyltransferase | |||||||||||||
Reaction: | UDP-β-L-rhamnose + a flavanone 7-O-β-D-glucoside = UDP + a flavanone 7-O-[α-L-rhamnosyl-(1→2)-β-D-glucoside] | |||||||||||||
For diagram of apigenin derivatives biosynthesis, click here, for diagram of luteolin derivatives biosynthesis, click here and for diagram of naringenin derivatives biosynthesis, click here | ||||||||||||||
Glossary: | UDP-β-L-rhamnose = UDP-6-deoxy-β-L-mannose | |||||||||||||
Other name(s): | UDP-rhamnose:flavanone-7-O-glucoside-2′′-O-rhamnosyltransferase; 1→2 UDP-rhamnosyltransferase; UDP-L-rhamnose:flavanone-7-O-glucoside 2′′-O-β-L-rhamnosyltransferase | |||||||||||||
Systematic name: | UDP-β-L-rhamnose:flavanone-7-O-glucoside 2′′-O-α-L-rhamnosyltransferase | |||||||||||||
Comments: | Acts on the 7-O-glucoside of naringenin and hesperetin, also the flavone 7-O-glucosides of luteolin and apigenin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 125752-89-8 | |||||||||||||
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EC | 1.1.1.243 | Relevance: 49.4% | ||||||||||||
Accepted name: | carveol dehydrogenase | |||||||||||||
Reaction: | (–)-trans-carveol + NADP+ = (–)-carvone + NADPH + H+ | |||||||||||||
For diagram of (–)-carvone, perillyl aldehyde and pulegone biosynthesis, click here | ||||||||||||||
Other name(s): | (–)-trans-carveol dehydrogenase | |||||||||||||
Systematic name: | (–)-trans-carveol:NADP+ oxidoreductase | |||||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 122653-66-1 | |||||||||||||
References: |
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EC | 5.5.1.28 | Relevance: 47.3% | ||||||||||||
Accepted name: | (–)-kolavenyl diphosphate synthase | |||||||||||||
Reaction: | geranylgeranyl diphosphate = (–)-kolavenyl diphosphate | |||||||||||||
For diagram of (–)-kolavenyl diphosphate derived diterpenoids, click here | ||||||||||||||
Glossary: | (–)-kolavenyl diphosphate = (2E)-5-[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-en-1-yl diposphate | |||||||||||||
Other name(s): | SdKPS; TwTPS14; TwTPS10/KPS; SdCPS2; clerodienyl diphosphate synthase; CLPP | |||||||||||||
Systematic name: | (–)-kolavenyl diphosphate lyase (ring-opening) | |||||||||||||
Comments: | Isolated from the hallucinogenic plant Salvia divinorum (seer’s sage) and the medicinal plant Tripterygium wilfordii (thunder god vine). | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 4.2.3.186 | Relevance: 47.3% | ||||||||||||
Accepted name: | ent-13-epi-manoyl oxide synthase | |||||||||||||
Reaction: | ent-8α-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate | |||||||||||||
For diagram of (–)-kolavenyl diphosphate derived diterpenoids, click here | ||||||||||||||
Glossary: | Ent-13-epi-manoyl oxide = (13R)-ent-8,13-epoxylabd-14-ene | |||||||||||||
Other name(s): | SmKSL2; ent-LDPP synthase | |||||||||||||
Systematic name: | ent-8α-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (cyclizing, ent-13-epi-manoyl-oxide-forming) | |||||||||||||
Comments: | Isolated from the plant Salvia miltiorrhiza (red sage). | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 4.2.3.95 | Relevance: 47% | ||||||||||||
Accepted name: | (-)-α-cuprenene synthase | |||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate = (-)-α-cuprenene + diphosphate | |||||||||||||
For diagram of biosynthesis of bicyclic sesquiterpenoids derived from bisabolyl cation, click here and for diagram of trichodiene and (–)-α-cuprenene biosynthesis, click here | ||||||||||||||
Other name(s): | Cop6 | |||||||||||||
Systematic name: | (-)-α-cuprenene hydrolase [cyclizing, (-)-α-cuprenene-forming] | |||||||||||||
Comments: | The enzyme from the fungus Coprinopsis cinerea produces (-)-α-cuprenene with high selectivity. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 4.2.3.6 | Relevance: 45.4% | ||||||||||||
Accepted name: | trichodiene synthase | |||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate = trichodiene + diphosphate | |||||||||||||
For diagram of biosynthesis of bicyclic sesquiterpenoids derived from bisabolyl cation, click here and for diagram of trichodiene and (–)-α-cuprenene biosynthesis, click here | ||||||||||||||
Other name(s): | trichodiene synthetase; sesquiterpene cyclase; trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase | |||||||||||||
Systematic name: | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming) | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 101915-76-8 | |||||||||||||
References: |
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EC | 1.14.13.104 | |||||||||||||
Transferred entry: | (+)-menthofuran synthase. Now EC 1.14.14.143, (+)-menthofuran synthase | |||||||||||||
EC | 1.3.99.25 | Relevance: 44.9% | ||||||||||||
Accepted name: | carvone reductase | |||||||||||||
Reaction: | (1) (+)-dihydrocarvone + acceptor = (–)-carvone + reduced acceptor (2) (–)-isodihydrocarvone + acceptor = (+)-carvone + reduced acceptor |
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For diagram of (–)-carvone catabolism, click here | ||||||||||||||
Glossary: | (+)-dihydrocarvone = (1S,4R)-menth-8-en-2-one (+)-isodihydrocarvone = (1S,4R)-menth-8-en-2-one (–)-carvone = (4R)-mentha-1(6),8-dien-6-one = (5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one |
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Systematic name: | (+)-dihydrocarvone:acceptor 1,6-oxidoreductase | |||||||||||||
Comments: | This enzyme participates in the carveol and dihydrocarveol degradation pathway of the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme has not been purified, and requires an unknown cofactor, which is different from NAD+, NADP+ or a flavin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.1.1.296 | Relevance: 44.5% | ||||||||||||
Accepted name: | dihydrocarveol dehydrogenase | |||||||||||||
Reaction: | menth-8-en-2-ol + NAD+ = menth-8-en-2-one + NADH + H+ | |||||||||||||
For diagram of (–)-carvone catabolism, click here | ||||||||||||||
Glossary: | (+)-dihydrocarveol = (1S,2S,4S)-menth-8-en-2-ol (+)-isodihydrocarveol = (1S,2S,4R)-menth-8-en-2-ol (+)-neoisodihydrocarveol = (1S,2R,4R)-menth-8-en-2-ol (–)-dihydrocarvone = (1S,4S)-menth-8-en-2-one (+)-isodihydrocarvone = (1S,4R)-menth-8-en-2-one |
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Other name(s): | carveol dehydrogenase (ambiguous) | |||||||||||||
Systematic name: | menth-8-en-2-ol:NAD+ oxidoreductase | |||||||||||||
Comments: | This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (–)-isodihydrocarveol. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.11.22 | |||||||||||||
Transferred entry: | flavone synthase. Now EC 1.14.20.5, flavone synthase | |||||||||||||
EC | 1.23.1.3 | Relevance: 43.1% | ||||||||||||
Accepted name: | (–)-pinoresinol reductase | |||||||||||||
Reaction: | (–)-lariciresinol + NADP+ = (–)-pinoresinol + NADPH + H+ | |||||||||||||
For diagram of (–)-lariciresinol biosynthesis, click here | ||||||||||||||
Glossary: | (–)-lariciresinol = 4-[(2R,3S,4S)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenol (–)-pinoresinol = (1R,3aS,4R,6aS)-4,4′-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol) |
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Other name(s): | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (–)-pinoresinol-(–)-lariciresinol reductase; PLR | |||||||||||||
Systematic name: | (–)-lariciresinol:NADP+ oxidoreductase | |||||||||||||
Comments: | The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol [EC 1.23.1.4, (–)-lariciresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1], Linum perenne (perennial flax) [2] and Arabidopsis thaliana (thale cress) [3]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | |||||||||||||
References: |
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EC | 1.14.13.47 | |||||||||||||
Transferred entry: | (S)-limonene 3-monooxygenase. Now EC 1.14.14.99, (S)-limonene 3-monooxygenase | |||||||||||||
EC | 3.1.1.83 | Relevance: 42.1% | ||||||||||||
Accepted name: | monoterpene ε-lactone hydrolase | |||||||||||||
Reaction: | (1) isoprop(en)ylmethyloxepan-2-one + H2O = 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction) (2) 4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate (3) 7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate |
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For diagram of (–)-carvone catabolism, click here and for diagram of menthol biosynthesis, click here | ||||||||||||||
Other name(s): | MLH | |||||||||||||
Systematic name: | isoprop(en)ylmethyloxepan-2-one lactonohydrolase | |||||||||||||
Comments: | The enzyme catalyses the ring opening of ε-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.13.48 | |||||||||||||
Transferred entry: | (S)-limonene 6-monooxygenase. Now classified as EC 1.14.14.51, (S)-limonene 6-monooxygenase | |||||||||||||
EC | 1.14.20.5 | Relevance: 41.7% | ||||||||||||
Accepted name: | flavone synthase I | |||||||||||||
Reaction: | a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O | |||||||||||||
For diagram of flavonoid biosynthesis, click here and for diagram of the biosynthesis of naringenin derivatives, click here | ||||||||||||||
Other name(s): | FNSI (gene name) | |||||||||||||
Systematic name: | flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) | |||||||||||||
Comments: | The enzyme, which has been found in rice and in members of the Apiaceae (a plant family), is a member of the 2-oxoglutarate-dependent dioxygenases, and requires ascorbate and Fe2+ for full activity. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 138263-98-6 | |||||||||||||
References: |
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EC | 2.3.1.146 | Relevance: 41.1% | ||||||||||||
Accepted name: | pinosylvin synthase | |||||||||||||
Reaction: | 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2 | |||||||||||||
For diagram of chalcone and stilbene biosynthesis, click here | ||||||||||||||
Other name(s): | stilbene synthase (ambiguous); pine stilbene synthase (ambiguous) | |||||||||||||
Systematic name: | malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing) | |||||||||||||
Comments: | Not identical with EC 2.3.1.74 (naringenin-chalcone synthase) or EC 2.3.1.95 (trihydroxystilbene synthase). | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 72994-49-1 | |||||||||||||
References: |
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EC | 1.14.13.49 | |||||||||||||
Transferred entry: | (S)-limonene 7-monooxygenase. Now classified as EC 1.14.14.52, (S)-limonene 7-monooxygenase | |||||||||||||
EC | 1.14.13.152 | |||||||||||||
Transferred entry: | geraniol 8-hydroxylase. Now EC 1.14.14.83, geraniol 8-hydroxylase | |||||||||||||
EC | 2.3.1.95 | Relevance: 40.1% | ||||||||||||
Accepted name: | trihydroxystilbene synthase | |||||||||||||
Reaction: | 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + trans-resveratrol + 4 CO2 | |||||||||||||
For diagram of chalcone and stilbene biosynthesis, click here | ||||||||||||||
Glossary: | trans-resveratrol = 3,4′,5-trihydroxy-trans-stilbene | |||||||||||||
Other name(s): | resveratrol synthase; stilbene synthase (ambiguous) | |||||||||||||
Systematic name: | malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) | |||||||||||||
Comments: | Not identical with EC 2.3.1.74 naringenin-chalcone synthase or EC 2.3.1.146 pinosylvin synthase. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 128449-70-7 | |||||||||||||
References: |
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EC | 2.1.1.46 | Relevance: 38.4% | ||||||||||||
Accepted name: | isoflavone 4′-O-methyltransferase | |||||||||||||
Reaction: | S-adenosyl-L-methionine + a 4′-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 4′-methoxyisoflavone | |||||||||||||
For diagram of the biosynthesis of biochanin A, click here and for diagram of the biosynthesis of formononetin and derivatives, click here | ||||||||||||||
Other name(s): | 4′-hydroxyisoflavone methyltransferase; isoflavone methyltransferase; isoflavone O-methyltransferase | |||||||||||||
Systematic name: | S-adenosyl-L-methionine:4′-hydroxyisoflavone 4′-O-methyltransferase | |||||||||||||
Comments: | Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55071-80-2 | |||||||||||||
References: |
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EC | 1.14.99.34 | Relevance: 38.4% | ||||||||||||
Accepted name: | monoprenyl isoflavone epoxidase | |||||||||||||
Reaction: | 7-O-methylluteone + NADPH + H+ + O2 = dihydrofurano derivatives + NADP+ + H2O | |||||||||||||
Glossary: | luteone = 3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one naringenin = 4′,5,7-trihydroxyflavan-4-one |
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Other name(s): | monoprenyl isoflavone monooxygenase; 7-O-methylluteone:O2 oxidoreductase; 7-O-methylluteone,NADPH:O2 oxidoreductase | |||||||||||||
Systematic name: | 7-O-methylluteone,NADPH:oxygen oxidoreductase | |||||||||||||
Comments: | A flavoprotein (FAD) with high specificity for monoprenyl isoflavone. The product of the prenyl epoxidation reaction contains an oxygen atom derived from O2, but not from H2O. It is slowly and non-enzymically converted into the corresponding dihydrofurano derivative. The enzyme in the fungus Botrytis cinerea is induced by the substrate analogue, 6-prenylnaringenin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 198496-86-5 | |||||||||||||
References: |
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EC | 1.14.14.162 | Relevance: 37.5% | ||||||||||||
Accepted name: | flavanone 2-hydroxylase | |||||||||||||
Reaction: | a flavanone + [reduced NADPH—hemoprotein reductase] + O2 = a 2-hydroxyflavanone + [oxidized NADPH—hemoprotein reductase] + H2O | |||||||||||||
For diagram of licodione biosynthesis, click here | ||||||||||||||
Other name(s): | CYP93G2 (gene name); CYP93B1 (gene name); (2S)-flavanone 2-hydroxylase; licodione synthase | |||||||||||||
Systematic name: | flavanone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating) | |||||||||||||
Comments: | A cytochrome P-450 (heme thiolate) plant enzyme that catalyses the 2-hydroxylation of multiple flavanones such as (2S)-naringenin, (2S)-eriodictyol, (2S)-pinocembrin, and (2S)-liquiritigenin. The products are meta-stable and exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.14.83 | Relevance: 36.6% | ||||||||||||
Accepted name: | geraniol 8-hydroxylase | |||||||||||||
Reaction: | geraniol + [reduced NADPH—hemoprotein reductase] + O2 = (6E)-8-hydroxygeraniol + [oxidized NADPH—hemoprotein reductase] + H2O | |||||||||||||
For diagram of acyclic monoterpenoid biosynthesis, click here | ||||||||||||||
Other name(s): | CYP76B6 (gene name); G10H (gene name) | |||||||||||||
Systematic name: | geraniol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating) | |||||||||||||
Comments: | A cytochrome P-450 (heme thiolate) protein found in plants. Also hydroxylates nerol and citronellol, cf. EC 1.14.14.84, linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature Pr-1. The cloned enzyme also catalysed, but less efficiently, the 3′-hydroxylation of naringenin (cf. EC 1.14.14.82, flavonoid 3′-monooxygenase) [3]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.13.105 | Relevance: 35.6% | ||||||||||||
Accepted name: | monocyclic monoterpene ketone monooxygenase | |||||||||||||
Reaction: | (1) (–)-menthone + NADPH + H+ + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O (2) dihydrocarvone + NADPH + H+ + O2 = 4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O (3) (iso)-dihydrocarvone + NADPH + H+ + O2 = 6-isopropenyl-3-methyloxepan-2-one + NADP+ + H2O (4a) 1-hydroxymenth-8-en-2-one + NADPH + H+ + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O (4b) 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate (spontaneous) |
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For diagram of (–)-carvone catabolism, click here, for diagram of limonene catabolism, click here and for diagram of menthol biosynthesis, click here | ||||||||||||||
Other name(s): | 1-hydroxy-2-oxolimonene 1,2-monooxygenase; dihydrocarvone 1,2-monooxygenase; MMKMO | |||||||||||||
Systematic name: | (–)-menthone,NADPH:oxygen oxidoreductase | |||||||||||||
Comments: | A flavoprotein (FAD). This Baeyer-Villiger monooxygenase enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 has wide substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones [2]. Both (1R,4S)- and (1S,4R)-1-hydroxymenth-8-en-2-one are metabolized, with the lactone product spontaneously rearranging to form 3-isopropenyl-6-oxoheptanoate [1]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 1.14.13.103 | |||||||||||||
Transferred entry: | 8-dimethylallylnaringenin 2-hydroxylase. Now EC 1.14.14.142, 8-dimethylallylnaringenin 2-hydroxylase | |||||||||||||
EC | 2.1.1.339 | Relevance: 35.3% | ||||||||||||
Accepted name: | xanthohumol 4-O-methyltransferase | |||||||||||||
Reaction: | S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol | |||||||||||||
For diagram of xanthohumol biosynthesis, click here | ||||||||||||||
Glossary: | xanthohumol = 2′,4,4′-trihydroxy-6′-methoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one 4-O-methylxanthohumol =2′,4′-dihydroxy-4,6′-dimethoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one |
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Other name(s): | OMT2 (ambiguous); S-adenosyl-L-methionine:xanthohumol 4′-O-methyltransferase (incorrect); xanthohumol 4′-O-methyltransferase (incorrect) | |||||||||||||
Systematic name: | S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase | |||||||||||||
Comments: | The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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EC | 2.5.1.71 | Relevance: 29.6% | ||||||||||||
Accepted name: | leachianone-G 2′′-dimethylallyltransferase | |||||||||||||
Reaction: | prenyl diphosphate + leachianone G = diphosphate + sophoraflavanone G | |||||||||||||
For diagram of sophoraflavanone G biosynthesis, click here | ||||||||||||||
Glossary: | dimethylallyl = prenyl = 3-methylbut-2-en-1-yl isopentenyl = 3-methylbut-3-en-1-yl lavandulyl = 5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl leachianone G = (–)-(2S)-2′-hydroxy-8-prenylnaringenin = (–)-(2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one sophoraflavanone G = (2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-2,3-dihydro-4H-chromen-4-one |
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Other name(s): | LG 2′′-dimethylallyltransferase; leachianone G 2′′-dimethylallyltransferase; LGDT; dimethylallyl-diphosphate:leachianone-G 2′′-dimethylallyltransferase | |||||||||||||
Systematic name: | prenyl-diphosphate:leachianone-G 2′′-prenyltransferase | |||||||||||||
Comments: | This membrane-bound enzyme is located in the plastids and requires Mg2+ for activity. The reaction forms the lavandulyl sidechain of sophoraflavanone G by transferring a prenyl group to the 2′′ position of another prenyl group attached at position 8 of leachianone G. The enzyme is specific for prenyl diphosphate as the prenyl donor, as it cannot be replaced by isopentenyl diphosphate or geranyl diphosphate. Euchrenone a7 (a 5-deoxy derivative of leachianone G) and kenusanone I (a 7-methoxy derivative of leachianone G) can also act as substrates, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2′-hydroxylase) and EC 2.5.1.70 (naringenin 8-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
References: |
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