|
Your query returned 6 entries. Printable version
EC | 1.14.19.51 | ||||||
Accepted name: | (S)-corytuberine synthase | ||||||
Reaction: | (S)-reticuline + [reduced NADPH—hemoprotein reductase] + O2 = (S)-corytuberine + [oxidized NADPH—hemoprotein reductase] + 2 H2O. | ||||||
For diagram of corytuberine and magnoflorine biosynthesis, click here | |||||||
Other name(s): | CYP80G2 | ||||||
Systematic name: | (S)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling; (S)-corytuberine-forming) | ||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine in the plant Coptis japonica. It is specific for (S)-reticuline. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
| ||||||
EC | 1.14.19.54 | ||||||
Accepted name: | 1,2-dehydroreticuline synthase | ||||||
Reaction: | (S)-reticuline + [reduced NADPH—hemoprotein reductase] + O2 = 1,2-dehydroreticuline + [oxidized NADPH—hemoprotein reductase] + 2 H2O | ||||||
For diagram of thebaine biosynthesis, click here | |||||||
Glossary: | reticuline = 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol | ||||||
Other name(s): | STORR; CYP82Y2 (gene name); DRS (gene name) | ||||||
Systematic name: | (S)-reticuline,[reduced NADPH—hemoprotein reductase]:oxygen 1,2-oxidoreductase | ||||||
Comments: | A P-450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
| ||||||
EC | 1.21.3.3 | ||||||
Accepted name: | reticuline oxidase | ||||||
Reaction: | (S)-reticuline + O2 = (S)-scoulerine + H2O2 | ||||||
For diagram of stylopine biosynthesis, click here | |||||||
Other name(s): | BBE; berberine bridge enzyme; berberine-bridge-forming enzyme; tetrahydroprotoberberine synthase | ||||||
Systematic name: | (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) | ||||||
Comments: | Contains FAD. The enzyme from the plant Eschscholtzia californica binds the cofactor covalently [3]. Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge (’berberine bridge’) of (S)-tetrahydroprotoberberines. The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 152232-28-5 | ||||||
References: |
| ||||||
EC | 2.1.1.116 | ||||||
Accepted name: | 3′-hydroxy-N-methyl-(S)-coclaurine 4′-O-methyltransferase | ||||||
Reaction: | S-adenosyl-L-methionine + 3′-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline | ||||||
For diagram of reticuline biosynthesis, click here | |||||||
Systematic name: | S-adenosyl-L-methionine:3′-hydroxy-N-methyl-(S)-coclaurine 4′-O-methyltransferase | ||||||
Comments: | Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3′-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 132084-81-2 | ||||||
References: |
| ||||||
EC | 2.1.1.291 | ||||||
Accepted name: | (R,S)-reticuline 7-O-methyltransferase | ||||||
Reaction: | (1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine (2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine |
||||||
For diagram of laudanine biosynthesis, click here | |||||||
Glossary: | (S)-reticuline = (1S)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (R)-reticuline = (1R)-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (S)-laudanine = 5-[((1S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-2-methoxyphenol (R)-laudanine = 5-[((1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-2-methoxyphenol |
||||||
Systematic name: | S-adenosyl-L-methionine:(R,S)-reticuline 7-O-methyltransferase | ||||||
Comments: | The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
| ||||||
EC | 2.1.1.337 | ||||||
Accepted name: | reticuline N-methyltransferase | ||||||
Reaction: | (1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-tembetarine (2) S-adenosyl-L-methionine + (S)-corytuberine = S-adenosyl-L-homocysteine + (S)-magnoflorine |
||||||
For diagram of corytuberine and magnoflorine biosynthesis, click here and for diagram of tembetarine biosynthesis, click here | |||||||
Glossary: | (S)-reticuline = (1S)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (S)-tembetarine = (1S)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-ol (S)-corytuberine = (6aS)-2,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,11-diol (S)-magnoflorine = (6aS)-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium |
||||||
Other name(s): | RNMT | ||||||
Systematic name: | S-adenosyl-L-methionine:(S)-reticuline N-methyltransferase | ||||||
Comments: | The enzyme from opium poppy (Papaver somniferum) can also methylate (R)-reticuline, tetrahydropapaverine, (S)-glaucine and (S)-bulbocapnine. It is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
| ||||||