The Enzyme Database

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Accepted name: ABC-type lipopolysaccharide transporter
Reaction: ATP + H2O + lipopolysaccharide[side 1] = ADP + phosphate + lipopolysaccharide[side 2]
Other name(s): lptB (gene name); lipopolysaccharide transport system; lipopolysaccharide-transporting ATPase
Systematic name: ATP phosphohydrolase (ABC-type, lipopolysaccharide-exporting)
Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzyme, characterized from the bacterium Escherichia coli, functions as part of the lipopolysaccharide (LPS) export system, a seven protein system that translocates LPS from the inner- to the outer membrane. The ATPase activity in this system is implicated in releasing LPS from the inner membrane.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB
1.  Sperandeo, P., Cescutti, R., Villa, R., Di Benedetto, C., Candia, D., Deho, G. and Polissi, A. Characterization of lptA and lptB, two essential genes implicated in lipopolysaccharide transport to the outer membrane of Escherichia coli. J. Bacteriol. 189 (2007) 244–253. [PMID: 17056748]
2.  Ruiz, N., Gronenberg, L.S., Kahne, D. and Silhavy, T.J. Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. Proc. Natl. Acad. Sci. USA 105 (2008) 5537–5542. [PMID: 18375759]
3.  Narita, S. and Tokuda, H. Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides. FEBS Lett. 583 (2009) 2160–2164. [PMID: 19500581]
4.  Tran, A.X., Dong, C. and Whitfield, C. Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli. J. Biol. Chem. 285 (2010) 33529–33539. [PMID: 20720015]
5.  Okuda, S., Freinkman, E. and Kahne, D. Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli. Science 338 (2012) 1214–1217. [PMID: 23138981]
6.  Chng, S.S., Gronenberg, L.S. and Kahne, D. Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex. Biochemistry 49 (2010) 4565–4567. [PMID: 20446753]
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