EC 7.4.2.9     
Accepted name: ABC-type dipeptide transporter
Reaction: ATP + H2O + a dipeptide-[dipeptide-binding protein][side 1] = ADP + phosphate + a dipeptide[side 2] + [dipeptide-binding protein][side 1]
Other name(s): dipeptide transporting ATPase; dipeptide ABC transporter; dppBCDF (gene names)
Systematic name: ATP phosphohydrolase (ABC-type, dipeptide-transporting)
Comments: ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of di- and tripeptides. The enzyme from Pseudomonas aeruginosa can interact with five different substrate binding proteins.
References:
1.  Abouhamad, W.N., Manson, M., Gibson, M.M. and Higgins, C.F. Peptide transport and chemotaxis in Escherichia coli and Salmonella typhimurium: characterization of the dipeptide permease (Dpp) and the dipeptide-binding protein. Mol. Microbiol. 5 (1991) 1035–1047. [PMID: 1956284]
2.  Sanz, Y., Lanfermeijer, F.C., Renault, P., Bolotin, A., Konings, W.N. and Poolman, B. Genetic and functional characterization of dpp genes encoding a dipeptide transport system in Lactococcus lactis. Arch. Microbiol. 175 (2001) 334–343. [PMID: 11409543]
3.  Li, X., Zhuo, W., Yu, J., Ge, J., Gu, J., Feng, Y., Yang, M., Wang, L. and Wang, N. Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain. Acta Crystallogr. D Biol. Crystallogr. 69 (2013) 256–265. [PMID: 23385461]
4.  Pletzer, D., Lafon, C., Braun, Y., Kohler, T., Page, M.G., Mourez, M. and Weingart, H. High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa. PLoS One 9:e111311 (2014). [PMID: 25338022]
[EC 7.4.2.9 created 2018]