Accepted name: arsenite-transporting ATPase
Reaction: ATP + H2O + arsenite[side 1] = ADP + phosphate + arsenite[side 2]
Other name(s): arsAB (gene names)
Systematic name: ATP phosphohydrolase (arsenite-exporting)
Comments: This bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. The enzyme usually contains two subunits where one (with 12 membrane-spanning segments) forms the ’channel’ part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. It forms an arsenite efflux pump that removes arsenite from the cytoplasm, and can also remove antimonite anions.
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2.  Rosen, B.P., Weigel, U., Monticello, R.A. and Edwards, B.P. Molecular analysis of an anion pump: purification of the ArsC protein. Arch. Biochem. Biophys. 284 (1991) 381–385. [PMID: 1703401]
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4.  Zhou, T., Rosen, B.P. and Gatti, D.L. Crystallization and preliminary X-ray analysis of the catalytic subunit of the ATP-dependent arsenite pump encoded by the Escherichia coli plasmid R773. Acta Crystallogr. D Biol. Crystallogr. 55 (1999) 921–924. [PMID: 10089335]
[EC created 2000 as EC, transferred 2019 to EC]