ExplorEnz: EC 7.2.2.9

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7.2.2.9

Accepted name:

P-type Cu²⁺ transporter

Reaction:

ATP + H₂O + Cu²⁺_{[side 1]} = ADP + phosphate + Cu²⁺_{[side 2]}

Other name(s):

Cu²⁺-exporting ATPase; copB (gene name)

Systematic name:

ATP phosphohydrolase (P-type, Cu²⁺-exporting)

Comments:

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic archaeon Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Mana-Capelli, S., Mandal, A.K. and Arguello, J.M. Archaeoglobus fulgidus CopB is a thermophilic Cu²⁺-ATPase: functional role of its histidine-rich-N-terminal metal binding domain. J. Biol. Chem. 278 (2003) 40534–40541. [DOI] [PMID: 12876283]
2.	Jayakanthan, S., Roberts, S.A., Weichsel, A., Arguello, J.M. and McEvoy, M.M. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle. Biosci Rep 32 (2012) 443–453. [DOI] [PMID: 22663904]

[EC 7.2.2.9 created 2000 as EC 3.6.3.4, modified 2013, transferred 2018 to EC 7.2.2.9]