| EC |
7.2.2.19 |
| Accepted name: |
H+/K+-exchanging ATPase |
| Reaction: |
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] |
| Other name(s): |
H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase |
| Systematic name: |
ATP phosphohydrolase (P-type,H+/K+-exchanging) |
| Comments: |
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Sachs, G., Collier, R.H., Shoemaker, R.L. and Hirschowitz, B.I. The energy source for gastric H+ secretion. Biochim. Biophys. Acta 162 (1968) 210–219. [DOI] [PMID: 5682852] |
| 2. |
Hersey, S.J., Perez, A. Matheravidathu, S. and Sachs, G. Gastric H+-K+-ATPase in situ: evidence for compartmentalization. Am. J. Physiol. 257 (1989) G539–G547. [DOI] [PMID: 2552824] |
| 3. |
Rabon, E.C. and Reuben, M.A. The mechanism and structure of the gastric H,K-ATPase. Annu. Rev. Physiol. 52 (1990) 321–344. [DOI] [PMID: 2158765] |
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| [EC 7.2.2.19 created 1984 as EC 3.6.1.36, transferred 2000 to EC 3.6.3.10, transferred 2018 to EC 7.2.2.19] |
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