| EC |
6.5.1.9 |
| Accepted name: |
cyclic 2,3-diphosphoglycerate synthase |
| Reaction: |
ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate |
| Other name(s): |
cpgS (gene name) |
| Systematic name: |
(2R)-2,3-bisphosphoglycerate ligase (cyclizing) |
| Comments: |
The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Lehmacher, A., Vogt, A.B. and Hensel, R. Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus. FEBS Lett. 272 (1990) 94–98. [PMID: 2226838] |
| 2. |
Matussek, K., Moritz, P., Brunner, N., Eckerskorn, C. and Hensel, R. Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus. J. Bacteriol. 180 (1998) 5997–6004. [PMID: 9811660] |
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| [EC 6.5.1.9 created 2020] |
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