| EC |
6.4.1.7 |
| Accepted name: |
2-oxoglutarate carboxylase |
| Reaction: |
ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate |
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For diagram of reaction, click here |
| Glossary: |
oxalosuccinate = 1-oxopropane-1,2,3-tricarboxylate |
| Other name(s): |
oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC |
| Comments: |
A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41 [2]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 60382-75-4 |
| References: |
| 1. |
Aoshima, M., Ishii, M. and Igarashi, Y. A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6. Mol. Microbiol. 51 (2004) 791–798. [DOI] [PMID: 14731279] |
| 2. |
Aoshima, M. and Igarashi, Y. A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6. Mol. Microbiol. 62 (2006) 748–759. [DOI] [PMID: 17076668] |
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| [EC 6.4.1.7 created 2006] |
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