The Enzyme Database

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Accepted name: acetone carboxylase
Reaction: acetone + hydrogen carbonate + 2 ATP + 3 H2O = acetoacetate + 2 AMP + 4 phosphate
Systematic name: acetone:carbon-dioxide ligase (AMP-forming)
Comments: Requires Mg2+ and ATP. The reaction involves separate phosphorylation of hydrogencarbonate and acetone, forming carboxyphosphate and phosphoenolacetone, respectively, which are combined to form the final product. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 189258-15-9
1.  Sluis, M.K. and Ensign, S.A. Purification and characterization of acetone carboxylase from Xanthobacter strain Py2. Proc. Natl. Acad. Sci. USA 94 (1997) 8456–8461. [DOI] [PMID: 9237998]
2.  Schuhle, K. and Heider, J. Acetone and butanone metabolism of the denitrifying bacterium Aromatoleum aromaticum demonstrates novel biochemical properties of an ATP-dependent aliphatic ketone carboxylase. J. Bacteriol. 194 (2012) 131–141. [PMID: 22020645]
[EC created 2001]

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