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Your query returned 1 entry. 
Printable version
| EC | 6.4.1.12 | ||||||
| Accepted name: | didemethylasterriquinone D synthase | ||||||
| Reaction: | 2 ATP + 2 (indol-3-yl)pyruvate = 2 AMP + 2 diphosphate + didemethylasterriquinone D (overall reaction) (1a) ATP + (indol-3-yl)pyruvate + [didemethylasterriquinone D synthase] = AMP + diphosphate + (indol-3-yl)pyruvoyl-[didemethylasterriquinone D synthase] (1b) ATP + (indol-3-yl)pyruvate + (indol-3-yl)pyruvoyl-[didemethylasterriquinone D synthase] = AMP + diphosphate + didemethylasterriquinone D + [didemethylasterriquinone D synthase] |
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| Glossary: | didemethylasterriquinone D = 3,6-dihydroxy-2,5-diindol-3′-yl-1,4-benzoquinone | ||||||
| Other name(s): | didemethylasterriquinone D synthetase; tdiA (gene name) | ||||||
| Systematic name: | (indol-3-yl)pyruvate:(indol-3-yl)pyruvate ligase (didemethylasterriquinone D-forming) | ||||||
| Comments: | Requires Mg2+. The enzyme, characterized from the fungus Aspergillus nidulans, is a non-ribosomal peptide synthase-like enzyme comprising three domains: an adelylation (A) domain, an ayl-carrier protein (ACP) domain and a thioesterase (TE) domain. The enzyme activates (indol-3-yl)pyruvate by adenylation and catalyses the dimerization/cyclization of two such molecules to form didemethylasterriquinone D. Didemethylasterriquinone D is subsequently converted to terrequinone A, a cytotoxic compound that displays a broad range of bioactivities. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
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