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Your query returned 1 entry. 
Printable version
| EC | 6.4.1.11 | ||||
| Accepted name: | polyporic acid synthase | ||||
| Reaction: | 2 ATP + 2 3-phenyl-2-oxopropanoate = 2 AMP + 2 diphosphate + polyporic acid (overall reaction) (1a) ATP + 3-phenyl-2-oxopropanoate + [polyporic acid synthase] = AMP + diphosphate + 3-pheny-2-oxopropanoyl-[polyporic acid synthase] (1b) ATP + 3-phenyl-2-oxopropanoate + 3-pheny-2-oxopropanoyl-[polyporic acid synthase] = AMP + diphosphate + polyporic acid + [polyporic acid synthase] |
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| Glossary: | polyporic acid = 2,5-dihydroxy-3,6-diphenylcyclohexa-2,5-diene-1,4-dione 3-phenyl-2-oxopropanoate = 3-phenylpyruvate |
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| Other name(s): | polyporic acid synthetase; corA (gene name); hapA1 (gene name); hapA2 (gene name) | ||||
| Systematic name: | 3-phenyl-2-oxopropanoate:3-phenyl-2-oxopropanoate ligase (polyporic acid-forming) | ||||
| Comments: | Requires Mg2+. The enzyme, found in mushrooms of the Basidiomycota and Ascomycota phyla, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-phenyl-2-oxopropanoate by adenylation and catalyses the dimerization/cyclization of two such molecules to form polyporic acid. Polyporic acid is a precursor for assorted metabolites produced by the fungi, such as the corticins. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
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