The Enzyme Database

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Accepted name: phosphoribosylformylglycinamidine synthase
Reaction: ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
For diagram of purine biosynthesis (early stages), click here
Other name(s): phosphoribosylformylglycinamidine synthetase; formylglycinamide ribonucleotide amidotransferase; phosphoribosylformylglycineamidine synthetase; FGAM synthetase; FGAR amidotransferase; 5′-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming); 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
Systematic name: N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9032-84-2
1.  Melnick, I. and Buchanan, J.M. Biosynthesis of the purines. I. Conversion of (α-N-formyl)glycinamide ribotide to (α-N-formyl)glycinamidine ribotide; purification and requirements of the enzyme system. J. Biol. Chem. 225 (1957) 157–162. [PMID: 13416226]
[EC created 1961, modified 2000]

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