| EC |
6.3.5.12 |
| Accepted name: |
Ni-sirohydrochlorin a,c-diamide synthase |
| Reaction: |
2 ATP + Ni-sirohydrochlorin + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate |
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| Other name(s): |
cfbB (gene name) |
| Systematic name: |
Ni-sirohydrochlorin:L-glutamine amido-ligase (ADP-forming) |
| Comments: |
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Zheng, K., Ngo, P.D., Owens, V.L., Yang, X.P. and Mansoorabadi, S.O. The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. Science 354 (2016) 339–342. [DOI] [PMID: 27846569] |
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| [EC 6.3.5.12 created 2017] |
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