The Enzyme Database

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Accepted name: formate—tetrahydrofolate ligase
Reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here
Other name(s): formyltetrahydrofolate synthetase; 10-formyltetrahydrofolate synthetase; tetrahydrofolic formylase; tetrahydrofolate formylase
Systematic name: formate:tetrahydrofolate ligase (ADP-forming)
Comments: In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP+) (EC and methenyltetrahydrofolate cyclohydrolase (EC activity.
Links to other databases: BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-66-9
1.  Jaenicke, L. and Brode, E. Untersuchungen über Einkohlenstoffkörper. I. Die Tetrahydrofolatformylase aus Taubenleber. Rinigung und Mechanismus. Biochem. Z. 334 (1961) 108–132. [PMID: 13789141]
2.  Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. Subunit structures and interactions of CTP synthetase. Fed. Proc. 28 (1969) 342.
3.  Rabinowitz, J.C. and Pricer, W.E. Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme. J. Biol. Chem. 237 (1962) 2898–2902. [PMID: 14489619]
4.  Whiteley, H.R., Osborn, M.J. and Huennekens, F.M. Purification and properties of the formate-activating enzyme from Micrococcus aerogenes. J. Biol. Chem. 234 (1959) 1538–1543. [PMID: 13654413]
[EC created 1961]

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