ExplorEnz: EC 6.3.4.25

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6.3.4.25

Accepted name:

2-amino-2′-deoxyadenylo-succinate synthase

Reaction:

ATP + dGMP + L-aspartate = ADP + phosphate + 2-amino-2′-deoxy-N⁶-[(2S)-succino]adenylate

Glossary:

dZTP = 2-amino-2′-deoxyadenosine 5′-triphosphate

Other name(s):

purZ (gene name)

Systematic name:

dGMP:L-aspartate ligase (ADP-forming)

Comments:

The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Zhou, Y., Xu, X., Wei, Y., Cheng, Y., Guo, Y., Khudyakov, I., Liu, F., He, P., Song, Z., Li, Z., Gao, Y., Ang, E.L., Zhao, H., Zhang, Y. and Zhao, S. A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science 372 (2021) 512–516. [DOI] [PMID: 33926954]
2.	Sleiman, D., Garcia, P.S., Lagune, M., Loc'h, J., Haouz, A., Taib, N., Rothlisberger, P., Gribaldo, S., Marliere, P. and Kaminski, P.A. A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes. Science 372 (2021) 516–520. [DOI] [PMID: 33926955]

[EC 6.3.4.25 created 2021]