The Enzyme Database

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Accepted name: 2-amino-2′-deoxyadenylo-succinate synthase
Reaction: ATP + dGMP + L-aspartate = ADP + phosphate + 2-amino-2′-deoxy-N6-[(2S)-succino]adenylate
Glossary: dZTP = 2-amino-2′-deoxyadenosine 5′-triphosphate
Other name(s): purZ (gene name)
Systematic name: dGMP:L-aspartate ligase (ADP-forming)
Comments: The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Zhou, Y., Xu, X., Wei, Y., Cheng, Y., Guo, Y., Khudyakov, I., Liu, F., He, P., Song, Z., Li, Z., Gao, Y., Ang, E.L., Zhao, H., Zhang, Y. and Zhao, S. A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science 372 (2021) 512–516. [DOI] [PMID: 33926954]
2.  Sleiman, D., Garcia, P.S., Lagune, M., Loc'h, J., Haouz, A., Taib, N., Rothlisberger, P., Gribaldo, S., Marliere, P. and Kaminski, P.A. A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes. Science 372 (2021) 516–520. [DOI] [PMID: 33926955]
[EC created 2021]

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