The Enzyme Database

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Accepted name: formate—dihydrofolate ligase
Reaction: ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate
Other name(s): formyltransferase, dihydrofolate; dihydrofolate formyltransferase; formyl dihydrofolate synthase
Systematic name: formate:dihydrofolate ligase (ADP-forming)
Comments: Not identical with EC (formate—tetrahydrofolate ligase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123303-25-3
1.  Drake, J.C., Baram, J. and Allegra, C.J. Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells. Biochem. Pharmacol. 39 (1990) 615–618. [DOI] [PMID: 2306274]
[EC created 1992]

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