ExplorEnz: EC 6.3.3.3

6.3.3.3

Accepted name:

dethiobiotin synthase

Reaction:

ATP + 7,8-diaminononanoate + CO₂ = ADP + phosphate + dethiobiotin

Other name(s):

desthiobiotin synthase

Systematic name:

7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)

Comments:

CTP has half the activity of ATP.

References:

1.	Krell, K. and Eisenberg, M.A. The purification and properties of dethiobiotin synthetase. J. Biol. Chem. 245 (1970) 6558–6566. [PMID: 4921568]
2.	Yang, H.-C., Tani, Y. and Ogata, K. Synthesis of biotin vitamers from biotin diaminocarboxylic acid or 7,8-diaminopelargonic acid by a purified enzyme of Pseudomonas graveolens. Agric. Biol. Chem. 34 (1970) 1748–1750.

[EC 6.3.3.3 created 1976]