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Your query returned 1 entry. Printable version
EC | 6.3.2.57 | ||
Accepted name: | staphyloferrin A synthase | ||
Reaction: | ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A | ||
For diagram of staphyloferrin A biosynthesis, click here | |||
Glossary: | staphyloferrin A = N2-[(R)-citryl],N5-[(S)-citryl]-D-ornithine citryl = 3-hydroxy-3,4-dicarboxybutanoyl |
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Other name(s): | sfnaB (gene name) | ||
Systematic name: | N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming) | ||
Comments: | Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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