| EC |
6.3.2.51 |
| Accepted name: |
phosphopantothenate—cysteine ligase (ATP) |
| Reaction: |
ATP + (R)-4′-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4′-phosphopantothenoyl]-L-cysteine |
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For diagram of the late stages of CoA biosynthesis, click here |
| Other name(s): |
phosphopantothenoylcysteine synthetase (ambiguous); PPCS (gene name) |
| Systematic name: |
(R)-4′-phosphopantothenate:L-cysteine ligase (ATP-utilizing) |
| Comments: |
A key enzyme in the production of coenzyme A. The eukaryotic enzyme requires ATP, in contrast to the bacterial enzyme, EC 6.3.2.5, phosphopantothenate—cysteine ligase (CTP), which requires CTP. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-50-1 |
| References: |
| 1. |
Daugherty, M. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J. Biol. Chem. 277 (2002) 21431–21439. [DOI] [PMID: 11923312] |
| 2. |
Manoj, N., Strauss, E., Begley, T.P. and Ealick, S.E. Structure of human phosphopantothenoylcysteine synthetase at 2.3 Å Resolution. Structure 11 (2003) 927–936. [DOI] [PMID: 12906824] |
| 3. |
Kupke, T., Hernandez-Acosta, P. and Culianez-Macia, F.A. 4′-phosphopantetheine and coenzyme A biosynthesis in plants. J. Biol. Chem. 278 (2003) 38229–38237. [DOI] [PMID: 12860978] |
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| [EC 6.3.2.51 created 2017] |
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