ExplorEnz: EC 6.2.1.76

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6.2.1.76

Accepted name:

malonate—CoA ligase

Reaction:

ATP + malonate + CoA = AMP + diphosphate + malonyl-CoA

Other name(s):

ACSF3 (gene name); AAE13 (gene name); malonyl-CoA synthetase

Systematic name:

malonate:CoA ligase (AMP-forming)

Comments:

The enzyme, found in mitochondria, detoxifies malonate, which is a potent inhibitor of mitochondrial respiration, and provides malonyl-CoA to the mitochondrial fatty acid biosynthesis pathway.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Gueguen, V., Macherel, D., Jaquinod, M., Douce, R. and Bourguignon, J. Fatty acid and lipoic acid biosynthesis in higher plant mitochondria. J. Biol. Chem. 275 (2000) 5016–5025. [DOI] [PMID: 10671542]
2.	Witkowski, A., Thweatt, J. and Smith, S. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. J. Biol. Chem. 286 (2011) 33729–33736. [DOI] [PMID: 21846720]
3.	Chen, H., Kim, H.U., Weng, H. and Browse, J. Malonyl-CoA synthetase, encoded by Acyl Activating Enzyme13, is essential for growth and development of Arabidopsis. Plant Cell 23 (2011) 2247–2262. [DOI] [PMID: 21642549]
4.	Guan, X. and Nikolau, B.J. AAE13 encodes a dual-localized malonyl-CoA synthetase that is crucial for mitochondrial fatty acid biosynthesis. Plant J. 85 (2016) 581–593. [DOI] [PMID: 26836315]
5.	Bowman, C.E., Rodriguez, S., Selen Alpergin, E.S., Acoba, M.G., Zhao, L., Hartung, T., Claypool, S.M., Watkins, P.A. and Wolfgang, M.J. The mammalian malonyl-CoA synthetase ACSF3 is required for mitochondrial protein malonylation and metabolic efficiency. Cell Chem. Biol. 24 (2017) 673–684.e4. [DOI] [PMID: 28479296]
6.	Bowman, C.E. and Wolfgang, M.J. Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism. Adv Biol Regul 71 (2019) 34–40. [DOI] [PMID: 30201289]

[EC 6.2.1.76 created 2022]