The Enzyme Database

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EC 6.2.1.65     
Accepted name: salicylate—CoA ligase
Reaction: ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA (overall reaction)
(1a) ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate
(1b) (2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA
Glossary: 2-hydroxybenzoyl-CoA = salicyloyl-CoA
Other name(s): sdgA (gene name)
Systematic name: salicylate:CoA ligase (AMP-forming)
Comments: The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Bonting, C.F. and Fuchs, G. Anaerobic metabolism of 2-hydroxybenzoic acid (salicylic acid) by a denitrifying bacterium. Arch. Microbiol. 165 (1996) 402–408. [PMID: 8661934]
2.  Ishiyama, D., Vujaklija, D. and Davies, J. Novel pathway of salicylate degradation by Streptomyces sp. strain WA46. Appl. Environ. Microbiol. 70 (2004) 1297–1306. [DOI] [PMID: 15006746]
[EC 6.2.1.65 created 2020]
 
 


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