ExplorEnz: EC 6.2.1.56

6.2.1.56

Accepted name:

4-hydroxybutyrate—CoA ligase (ADP-forming)

Reaction:

ATP + 4-hydroxybutanoate + CoA = ADP + phosphate + 4-hydroxybutanoyl-CoA

Other name(s):

Nmar_0206 (locus name)

Systematic name:

4-hydroxybutanoate:CoA ligase (ADP-forming)

Comments:

The enzyme, characterized from the marine ammonia-oxidizing archaeon Nitrosopumilus maritimus, participates in a variant of the 3-hydroxypropanoate/4-hydroxybutanate CO₂ fixation cycle. cf. EC 6.2.1.40, 4-hydroxybutyrate—CoA ligase (AMP-forming).

References:

Konneke, M., Schubert, D.M., Brown, P.C., Hugler, M., Standfest, S., Schwander, T., Schada von Borzyskowski, L., Erb, T.J., Stahl, D.A. and Berg, I.A. Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO₂ fixation. Proc. Natl. Acad. Sci. USA 111 (2014) 8239–8244. [PMID: 24843170]

[EC 6.2.1.56 created 2019]