| EC |
6.2.1.47 |
| Accepted name: |
medium-chain-fatty-acid—[acyl-carrier-protein] ligase |
| Reaction: |
ATP + a medium-chain fatty acid + a holo-[acyl-carrier protein] = AMP + diphosphate + a medium-chain acyl-[acyl-carrier protein] |
| Other name(s): |
jamA (gene name) |
| Systematic name: |
medium-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming) |
| Comments: |
The enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 77322-37-3 |
| References: |
| 1. |
Edwards, D.J., Marquez, B.L., Nogle, L.M., McPhail, K., Goeger, D.E., Roberts, M.A. and Gerwick, W.H. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem. Biol. 11 (2004) 817–833. [DOI] [PMID: 15217615] |
| 2. |
Zhu, X., Liu, J. and Zhang, W. De novo biosynthesis of terminal alkyne-labeled natural products. Nat. Chem. Biol. 11 (2015) 115–120. [DOI] [PMID: 25531891] |
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| [EC 6.2.1.47 created 2016] |
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