EC |
6.2.1.33 |
Accepted name: |
4-chlorobenzoate—CoA ligase |
Reaction: |
4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate |
Systematic name: |
4-chlorobenzoate:CoA ligase |
Comments: |
Requires Mg2+. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141583-20-2 |
References: |
1. |
Dunaway-Mariano, D., Babbitt, P.C. On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway. Biodegradation 5 (1994) 259–276. [PMID: 7765837] |
2. |
Loffler, F., Muller, R., Lingens, F. Purification and properties of 4-halobenzoate-coenzyme A ligase from Pseudomonas sp. CBS3. Biol. Chem. Hoppe-Seyler 373 (1992) 1001–1007. [PMID: 1418673] |
3. |
Chang, K.H., Liang, P.H., Beck, W., Scholten, J.D., Dunaway-Mariano, D. Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3. Biochemistry 31 (1992) 5605–5610. [PMID: 1610806] |
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[EC 6.2.1.33 created 1999] |
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