The Enzyme Database

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Accepted name: acetoacetate—CoA ligase
Reaction: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA
For diagram of mevalonate biosynthesis, click here
Other name(s): acetoacetyl-CoA synthetase
Systematic name: acetoacetate:CoA ligase (AMP-forming)
Comments: Also acts, more slowly, on L-3-hydroxybutanoate.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 39394-62-2
1.  Fukui, T., Ito, M. and Tomita, K. Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M. Eur. J. Biochem. 127 (1982) 423–428. [DOI] [PMID: 7140777]
[EC created 1984]

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