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Your query returned 1 entry. Printable version
EC | 6.1.2.1 | ||||||
Accepted name: | D-alanine—(R)-lactate ligase | ||||||
Reaction: | D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate | ||||||
Glossary: | (R)-lactate = D-lactate D-alanyl-(R)-lactate = D-alanyl-D-lactate = (2R)-2-(D-alanyloxy)propanoic acid = (R)-2-((R)-2-aminopropanoyloxy)propanoic acid |
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Other name(s): | VanA; VanB; VanD | ||||||
Systematic name: | D-alanine:(R)-lactate ligase (ADP-forming) | ||||||
Comments: | The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine—D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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