The Enzyme Database

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EC 5.5.1.18     
Accepted name: lycopene ε-cyclase
Reaction: carotenoid ψ-end group = carotenoid ε-end group
For diagram of α-, β-, γ-, δ- and ε-carotene biosynthesis, click here and for diagram of reaction, click here
Other name(s): CrtL-e; LCYe; carotenoid ψ-end group lyase (decyclizing)
Systematic name: carotenoid ψ-end group lyase (ring-opening)
Comments: The carotenoid lycopene has the ψ-end group at both ends. When acting on one end, this enzyme forms δ-carotene. When acting on both ends, it forms ε-carotene.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc
References:
1.  Cunningham, F.X., Jr. and Gantt, E. One ring or two? Determination of ring number in carotenoids by lycopene ε-cyclases. Proc. Natl. Acad. Sci. USA 98 (2001) 2905–2910. [DOI] [PMID: 11226339]
2.  Stickforth, P., Steiger, S., Hess, W.R. and Sandmann, G. A novel type of lycopene ε-cyclase in the marine cyanobacterium Prochlorococcus marinus MED4. Arch. Microbiol. 179 (2003) 409–415. [DOI] [PMID: 12712234]
[EC 5.5.1.18 created 2011]
 
 


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