ExplorEnz: EC 5.4.99.60

Your query returned 1 entry. Printable version

5.4.99.60

Accepted name:

cobalt-precorrin-8 methylmutase

Reaction:

cobalt-precorrin-8 = cobyrinate

For diagram of anaerobic corrin biosynthesis (part 2), click here

Other name(s):

cbiC (gene name)

Systematic name:

precorrin-8 11,12-methylmutase

Comments:

The enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement. The equivalent enzyme in the aerobic pathway is EC 5.4.99.61, precorrin-8X methylmutase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Roessner, C.A., Warren, M.J., Santander, P.J., Atshaves, B.P., Ozaki, S., Stolowich, N.J., Iida, K., Scott, A.I. Expression of Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis. FEBS Lett. 301 (1992) 73–78. [DOI] [PMID: 1451790]
2.	Roth, J.R., Lawrence, J.G., Rubenfield, M., Kieffer-Higgins, S., Church, G.M. Characterization of the cobalamin (vitamin B₁₂) biosynthetic genes of Salmonella typhimurium. J. Bacteriol. 175 (1993) 3303–3316. [DOI] [PMID: 8501034]
3.	Xue, Y., Wei, Z., Li, X. and Gong, W. The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis. J. Struct. Biol. 153 (2006) 307–311. [DOI] [PMID: 16427313]
4.	Moore, S.J., Lawrence, A.D., Biedendieck, R., Deery, E., Frank, S., Howard, M.J., Rigby, S.E. and Warren, M.J. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B₁₂). Proc. Natl. Acad. Sci. USA 110 (2013) 14906–14911. [DOI] [PMID: 23922391]

[EC 5.4.99.60 created 2014]