The Enzyme Database

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EC 5.4.99.38     
Accepted name: camelliol C synthase
Reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C
Other name(s): CAMS1; LUP3 (gene name)
Systematic name: (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)
Comments: The product is 97% camelliol, 2% achilleol A and 0.2% β-amyrin. Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system. This enzyme probably evolved from EC 5.4.99.39, β-amyrin synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kolesnikova, M.D., Wilson, W.K., Lynch, D.A., Obermeyer, A.C. and Matsuda, S.P. Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles. Org. Lett. 9 (2007) 5223–5226. [DOI] [PMID: 17985917]
[EC 5.4.99.38 created 2011]
 
 


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