| EC |
5.3.99.3 |
| Accepted name: |
prostaglandin-E synthase |
| Reaction: |
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11α,15-dihydroxy-9-oxoprosta-5,13-dienoate |
| Other name(s): |
prostaglandin-H2 E-isomerase; endoperoxide isomerase; endoperoxide isomerase; prostaglandin R-prostaglandin E isomerase; prostaglandin endoperoxide E isomerase; PGE isomerase; PGH-PGE isomerase; PGE2 isomerase; prostaglandin endoperoxide E2 isomerase; prostaglandin H-E isomerase |
| Systematic name: |
(5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase |
| Comments: |
Brings about the opening of the epidioxy bridge. Requires glutathione. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 52227-79-9 |
| References: |
| 1. |
Ogino, N., Miyamoto, T., Yamamoto, S. and Hayaishi, O. Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme. J. Biol. Chem. 252 (1977) 890–895. [PMID: 838703] |
| 2. |
Tanaka, Y., Ward, S.L. and Smith, W.L. Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes. J. Biol. Chem. 262 (1987) 1374–1381. [PMID: 3100531] |
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| [EC 5.3.99.3 created 1976, modified 1990] |
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